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AssigneeUniversity of Maryland Biotechnology Institute
InventorsAllen R. Place, Moti Harel
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A method of enhancing a culturing characteristic of fish larvae, including administering to said larvae in a nutritional diet essential fatty acids including DHA and AA in a ratio effective to enhance the culturing characteristic of such fish larvae relative to a corresponding nutritional diet lacking DHA and AA. The culturing characteristic may be at least one of stress resistance, immunoresistance, hatching rate, and growth rate. In a preferred aspect, the DHA and AA together comprise from about 10 to about 30% of total fatty acids in enrichment lipids, and the dietary ratio of DHA: AA is less than 10. The invention also contemplates a method of operating an aquaculture facility, including growing heterotrophic algae and/or fungi in a fermentor under growth conditions therefor, to produce a heterotrophic cellular product containing DHA and AA, and feeding the heterotrophic cellular product and/or one or more components thereof to (i) fish larvae and/or broodstock in the aquaculture facility, or (ii) live food subsequently fed to such fish larvae.
A method of using a culturing medium to enhance stress and defense mechanisms of fish larvae, comprising:
A method of increasing survival of fish larvae exposed to environmental stress, comprising administering to said larvae a nutritional diet comprising docosahexaenoic acid (DHA) and arachidonacid (AA) in a ratio DHA:AA effective to increase survival of larvae exposed to environmental stresses, wherein the ratio ranges from about 4 to about 0.75, and wherein the DHA and AA together comprise from about 10 to about 30% of total fatty acids in said diet.
A method of enhancing stress resistance and survival of fish larvae to hyperosmotic conditions, comprising administering to said larvae in a nutritional diet essential fatty acids comprising docosahexaenoic acid (DHA) and arachidonacid (AA) in a ratio effective to enhance stress resistance and survival of fish larvae to said hyperosmotic conditions, and wherein the ratio ranges from about 4 to about 0.75.
A method of enhancing stress resistance of fish larvae to a pathogenic infection, comprising administering to said larvae in a nutritional diet essential fatty acids comprising docosahexaenoic acid (DHA) and arachidonic acid (AA) in a ratio ranging from about 4 to about 0.75 to enhance stress resistance of fish larvae to pathogenic infection of less than 10 and effective to substantially increase blood count of monocytes and neutrophils in exposure to said microbial infection, relative to levels produced by said fish larvae in response to exposure to said pathogenic infection when the larvae is fed a corresponding nutritional diet lacking the effective ratio.
Dependencies are inferred from the claim text.