Compositions and methods for systemic inhibition of cartilage degradation
AssigneeOmeros Corporation
InventorsGregory A. Demopulos, Pamela Pierce Palmer, Jeffrey M. Herz
Life of this patent
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Abstract
Methods and compositions for inhibiting articular cartilage degradation. The compositions preferably include multiple chondroprotective agents, including at least one agent that promotes cartilage anabolic activity and at least one agent that inhibits cartilage catabolism. The compositions may also include one or more pain and inflammation inhibitory agents. The compositions may be administered systemically, such as to treat patients at risk of cartilage degradation at multiple joints, and suitably may be formulated in a carrier or delivery vehicle that is targeted to the joints. Alternatively the compositions may be injected or infused directly into the joint.
Claims41
A targeted drug delivery system for the protection of cartilage, comprising a plurality of chondroprotective agents, wherein at least one of the chondroprotective agents is contained within a delivery vehicle, the delivery vehicle being coupled to an antibody or antibody fragment that is specific to an antigenic determinant localized within the joint, the plurality of chondroprotective agents comprising at least one anabolic chondroprotective agent and at least one inhibitor of cartilage catabolism, each being included in therapeutically effective amounts such that the plurality of chondroprotective agents both inhibit cartilage catabolism and promote cartilage anabolism.
A method of protecting cartilage in a patient, comprising:
- delivering to the patient in need thereof a targeted drug delivery system comprising a plurality of chondroprotective agents contained within a delivery vehicle, the delivery vehicle being coupled to an antibody or antibody fragment that is specific to an antigenic determinant localized within the joint, the plurality of chondroprotective agents comprising at least one anabolic chondroprotective agent and at least one inhibitor of cartilage catabolism, each being included in therapeutically effective amounts such that the plurality of chondroprotective agents both inhibit cartilage catabolism and promote cartilage anabolism.
A method of protecting cartilage in a patient, comprising:
- concurrently administrating to the patient in need thereof a plurality of chondroprotective agents, wherein at least one of the chondroprotective agents is contained within a delivery vehicle, the delivery vehicle being coupled to an antibody or antibody fragment that is specific to an antigenic determinant localized within the joint, the plurality of chondroprotective agents comprising at least one anabolic chondroprotective agent and at least one inhibitor of cartilage catabolism, the plurality of chondroprotective agents each being included in therapeutically effective amounts such that the plurality of chondroprotective agents both inhibit cartilage catabolism and promote cartilage anabolism.
A method of protecting cartilage in a patient, comprising:
- administering to the patient in need thereof a plurality of chondroprotective agents, wherein at least one of the chondroprotective agents is contained within a delivery vehicle and the chondroprotective agents are administered so as to result in the coincident presence of the chondroprotective agents within the joint, the delivery vehicle being coupled to an antibody or antibody fragment that is specific to an antigenic determinant localized within the joint, the plurality of chondroprotective agents comprising at least one anabolic chondroprotective agent and at least one inhibitor of cartilage catabolism, each being included in therapeutically effective amounts such that the plurality of chondroprotective agents both inhibit cartilage catabolism and promote cartilage anabolism.
Dependencies are inferred from the claim text.