Methods and compositions for diseases associated with amyloidosis
AssigneesAventis Pharma S.A., Universite Louis Pasteur
InventorYves Claude Nicolau
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Abstract
The present invention generally relates to the detection, treatment or prevention of disease states. Specifically, the present invention relates to the detection, treatment or prevention of amyloidosis or amyloid-associated diseases. The present invention further comprises methods and compositions comprising therapeutic vaccines, antisera and molecular constructs, comprising expression vectors and fusion proteins encoded therein.
Claims12
A composition comprising modified amyloid beta1-16 peptide consisting of amino acids 1–16 of the amyloid beta peptide, wherein the modification consists of one or more covalently bonded lipophilic moieties and wherein the lipophilic moieties are palmitoylated lysines.
A composition comprising a modified amyloid beta1-16 peptide consisting of amino acids 1–16 of the amyloid beta peptide, wherein the modification consists of one or more covalently bonded lipophilic moieties added to an N terminus of a C terminus of the amyloid beta1-16 peptide wherein the one or more covalently bonded lipophilic moieties are one or more palmitoylated lysines.
A composition comprising a modified amyloid beta1-16 peptide consisting of amino acids 1–16 of the amyloid beta peptide anchored to a liposomal bilayer, wherein the modified amyloid beta1-16 peptide consists of covalently bonded lipophilic moieties, wherein at least one of the covalently bonded lipophilic moieties is added to a C-terminus of the modified amyloid beta1-16 peptide and at least one of the covalently bonded lipophilic moieties is added to an N-terminus of the modified amyloid beta1-16 peptide, and wherein the modified amyloid beta1-16 peptide is anchored to the liposomal bilayer by at least one of the covalently bonded lipophilic moieties, wherein the covalently bonded lipophilic moieties are palmitoylated lysines.
Dependencies are inferred from the claim text.