Polyspecific immunoconjugates and antibody composites for targeting the multidrug resistant phenotype
AssigneeImmunomedics, Inc.
InventorDavid M. Goldenberg
Life of this patent
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Abstract
Polyspecific immunoconjugates and antibody composites that bind a multidrug transporter protein and an antigen associated with a tumor or infectious agent are used to overcome the multidrug resistant phenotype. These immunoconjugates and composites also can be used diagnostically to determine whether the failure of traditional chemotherapy is due to the presence of multidrug resistant tumor cells, multidrug resistant HIV-infected cells or multidrug resistant infectious agents.
Claims10
A method for treating a mammal having either a multidrug resistant tumor that expresses a tumor associated antigen or a multidrug resistant disease caused by an infectious agent, said method comprising the step of administering an antibody composite to the mammal, wherein said antibody composite comprises:
- (a) at least one antibody component that binds with a first epitope of a multidrug transporter protein, and
- (b) at least one antibody component that binds with a first epitope of an antigen, wherein said antigen is associated with said tumor or said infectious agent.
Dependencies are inferred from the claim text.