Human aminoacyl-tRNA synthetase polypeptides useful for the regulation of angiogenesis
AssigneeThe Scripps Research Institute
InventorsPaul Schimmel, Keisuke Wakasugi
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Abstract
Compositions comprising truncated tryptophanyl-tRNA synthetase polypeptides useful for regulating angiogenesis, as well as nucleic acids encoding such tRNA synthetase polypeptides are described. Methods of making and using such compositions are also disclosed.
Claims14
An isolated amino-terminal truncated human tryptophanyl-tRNA synthetase polypeptide capable of regulating angiogenesis comprising a carboxyl-terminal portion of SEQ ID NO:
- 10, which includes a Rossmann fold nucleotide binding domain.
An isolated polypeptide which is an amino-terminal truncated human tryptophanyl-tRNA synthetase polypeptide having chemokine activity comprising a carboxyl-terminal portion of SEQ ID NO:
- 10, which includes a Rossmann fold nucleotide binding domain.
Dependencies are inferred from the claim text.