High refractive index compositions useful for intraocular lenses and methods for making same
AssigneeAdvanced Medical Optics, Inc.
InventorMichael D. Lowery
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Abstract
An intraocular lens suitable for implantation into an eye has an optically clear, deformable lens body composed of a silicone polymer and a silica reinforcer that structurally reinforces the polymer. The silica reinforcer is chemically modified with aryl groups effective to increase the refractive index of the silica reinforcer, preferably so as to substantially match the refractive index of the silicone polymer.
Claims30
An intraocular lens for surgical implantation into a mammalian eye having a deformable lens body including an optically clear material comprising:
- a silicone polymer;
- and
- a silica reinforcer present in an amount effective to reinforce said polymer, the silica reinforcer including at least one aryl group effective to increase the refractive index of the silica reinforcer relative to a similar silica reinforcer without at least one aryl group, wherein the silica reinforcer has a refractive index greater than about 1.50.
A composition comprising:
- a silicone polymer;
- and
- a silicone reinforcer present in an amount effective to reinforce said polymer, the silica reinforcer including at least one aryl group effective to increase the refractive index of the silica reinforcer relative to a similar silica reinforcer without at least one aryl group,
- wherein the silicone polymer includes at least one polysiloxane of the formula:
- wherein each R is independently selected from the group consisting of alkyl radicals, substituted alkyl radicals, cycloalkyl radicals, substituted cycloalkyl radicals, aryl radicals and substituted aryl radicals, each R1 is independently selected from the group consisting of divalent hydrocarbon radicals and substituted divalent hydrocarbon radicals, each R2 is independently selected from the group consisting of aryl radicals and substituted aryl radicals, each R3 is independently selected from the group consisting of monovalent hydrocarbon radicals having a carbon-carbon multiple bond and substituted hydrocarbon radicals having a carbon-carbon multiple bond, x is an integer in a range of 0 to about 500, and y is an integer in a range of about 6 to about 500.
A polysiloxane compound having the following formula:
- wherein each R is independently selected from the group consisting of alkyl radicals, substituted alkyl radicals, cycloalkyl radicals, substituted cycloalkyl radicals, aryl radicals and substituted aryl radicals, each R1 is independently selected from the group consisting of divalent hydrocarbon radicals and substituted divalent hydrocarbon radicals, each R2 is independently selected from the group consisting of aryl radicals and substituted aryl radicals, each R3 is independently selected from the group consisting of monovalent hydrocarbon radicals having a carbon-carbon multiple bond and substituted hydrocarbon radicals having a carbon-carbon multiple bond, x is an integer in a range of 0 to about 500, and y is an integer in a range of about 6 to about 500.
An intraocular lens for surgical implantation into a mammalian eye having a deformable lens body including an optically clear material comprising:
- a silicone polymer;
- and
- a silica reinforcer present in an amount effective to reinforce said polymer, the silica reinforcer including at least one aryl group effective to increase the refractive index of the silica reinforcer relative to a similar silica reinforcer without at least one aryl group, wherein the silica reinforcer has a refractive index greater than about 1.47;
- and
- wherein the silicone polymer has a refractive index, and wherein the refractive index of the silica reinforcer is within about 0.015 of the refractive index of the silicone polymer.
Dependencies are inferred from the claim text.