Removal of metabolic components from blood
AssigneeLife Therapeutics Limited
InventorsSteven Anthony Botto, Philip John Roeth, Ellie Louise Faramus, Chenicheri Hariharan Nair
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Abstract
An electrophoresis system for removing or reducing concentration of a metabolic component from blood or plasma of a subject is provided. A method for removing or reducing concentration or amount of a metabolic component in blood or plasma of a subject is also provided. The system and method include use of a set of ion permeable barriers and the application of an electrical potential across these barriers to selectively remove metabolic components from blood or plasma.
Claims30
An electrophoresis system for removing or reducing concentration of a metabolic component from blood or plasma of a subject, comprising:
- (a) a first ion-permeable barrier having a defined pore size and pore size distribution disposed in an electric field area;
- (b) a second ion-permeable barrier having defined pore size and pore size distribution disposed between a cathode zone and the first barrier so as to define a treatment chamber therebetween;
- (c) means adapted for cooling blood or plasma from the subject;
- (d) means adapted to provide dialysate to the cathode zone and an anode zone;
- (e) means adapted to provide blood or plasma from the subject to the treatment chamber;
- wherein, upon application of the electric potential, a metabolic component from the blood or plasma moves through at least one barrier into at least one of the cathode or anode zones, and wherein the barriers forming the treatment chamber are provided as a cartridge or cassette positioned between the electrode zones of the system.
A method for removing or reducing the concentration or amount of a metabolic component in blood or plasma of a subject, the method comprising:
- (a) placing blood or plasma from the subject in a treatment chamber of an electrophoresis system comprising a first ion-permeable barrier having a defined pore size and pore size distribution disposed in an electric field area;
- a second ion-permeable barrier having a defined pore size and pore size distribution disposed between a cathode zone and the first barrier so as to define a treatment chamber therebetween;
- means adapted for cooling blood or plasma from the subject;
- means adapted to provide dialysate to the cathode zone and an anode zone;
- and means adapted to provide blood or plasma or plasma from the subject to the treatment chamber, wherein the barriers forming the treatment chamber are provided as a cartridge or cassette positioned between the electrode zones of the system;
- (b) applying an electric potential between the cathode and anode causing movement of a metabolic component from the blood or plasma though a barrier into at least one of the electrode zones;
- (c) maintaining step (b) until the desired amount of removal of the metabolic component from the blood or plasma is achieved;
- and
- (d) returning the treated blood plasma in the treatment chamber to the subject, wherein the method substantially does not result in the blood or plasma being heated above physiological temperature of about 37° C.
Dependencies are inferred from the claim text.