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US 7,064,236 B2Granted
Substituted 1-aryl-but-3-enylamine and 1-aryl-but-2-enylamine compounds
AssigneeGrüNenthal GmbH
InventorsBernd Sundermann, Corinna Sundermann, Helmut Buschmann, Babette-Yvonne Koegel
Life of this patent
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Abstract
The invention relates to substituted 1-aryl-but-3-enylamine and 1-aryl-but-2-enylamine compounds, to a method for the production thereof, to medicaments containing said compounds and to their use in the production of medicaments.
Claims34
Substituted 1-aryl-but-3-enylamine and 1-aryl-but-2-enylamine compounds of the formula I,
- in which
- R1 and R2, identical or different, denote a C1-6 alkyl group or together form a ring as (CH2)2-6, which may also be substituted or benzo-fused with at least one optionally at least mono-substituted aryl or heteroaryl group,
- R3 denotes a C3-6 alkyl, a C3-7 cycloalkyl, an optionally at least mono-substituted aryl or heteroaryl group or an optionally at least mono-substituted aryl or heteroaryl group attached via a C1-3 alkylene group,
- R4 and R5, identical or different, denote a C1-6 alkyl, a C3-7 cycloalkyl, a phenyl, a benzyl or a phenethyl group or R4 and R5 together form a ring as (CH2)3-6 or —CH2—CH2—O—CH2—CH2,
- X and Y or Y and Z together denote a bond,
- A denotes an optionally at least mono-substituted aryl or heteroaryl group,
- in the form of the racemates, diastereomers or enantiomers thereof as a free base or a corresponding physiologically acceptable salt.
4 more elements
Dependencies are inferred from the claim text.