Enantioselective cation-exchange materials
OwnerWolfgang Lindner, Michael Lammerhoferinventors
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Abstract
The present invention relates to an enantioselective cation-exchange material, comprising a chiral selector (1), composed of a chiral component (2) and at least one cation-exchange group (X), a spacer (3) and a carrier (4). The cation-exchange material is characterized in that the chiral component (2) has a molecular weight of less than 1,000 and the at least one cation-exchange group (X) is an acid group having a pKa<4.0.
Claims14
An enantioselective cation-exchange material, comprising a chiral selector comprising a chiral component and at least one cation-exchange group, a spacer and a carrier, wherein
- the chiral component has a molecular weight of less than 1,000 and comprises a π—π interaction site and wherein the at least one cation-exchange group is an acid group having a pKa<4.0.
An enantioselective cation-exchange material which comprises a chiral selector comprising a chiral component and at least one cation-exchange group, a spacer end a carrier, wherein
- (a) the chiral component has a molecular weight of less than 1,000 and comprises a π—π interaction site;
- (b) the at least one cation exchange group is an acid group having a pKa<4.0 and comprised of a sulfonic, sulfinic, phosphoric, phosphonic, phosphinic, boronic, amidophosphonic or amidosulfonic group;
- (c) said carrier comprises a member selected from the group consisting of silica (SiO2), alumina (Al2O3), zirconia (ZrO2), titania (TiO2), matrices produced by sol-gel technology, organic-inorganic silica-containing hybrid materials, polysiloxanes, poly(meth)acrylates, poly(meth)acrylamides, polystyrenes, styrene-(meth)acrylate plymers, ring-opening methathesis polymers, polysaccharides, and agarose;
- and
- (d) said spacer is of the formula
- —(CH2)ni—Y—(CH2)nj—
- wherein Y is missing or is a member selected from the group consisting of:
- wherein n, ni and nj are each separately an integer between 1 and 18.
An enantioselective cation-exchange material which comprises a chiral selector comprising a chiral component and at least one cation-exchange group, a spacer and a carrier, wherein
- (a) the chiral component has a molecular weight of less than 1,000 and comprises a π—π interaction site;
- (b) the at least one cation-exchange group is an acid group having a pKa<4.0 comprised of a member selected from the group consisting of —COOH, —PO(OH)2, —SO3H, —OPO(OH)2, —B(OH)2, and —CH2—SO3H;
- (c) said carrier is a member selected from the group consisting of silicon beads, poly(meth)acrylate polymer beads, poly(meth)acrylamide beads, poly(meth)acrylate monoliths, and polystyrene resins;
- (d) said spacer is of the formula
- —(CH2)ni—Y—(CH2)nj—
- wherein Y is missing or is a member selected from the group consisting of:
- wherein n, ni and nj are each separately an integer between and 1 and 18.
Dependencies are inferred from the claim text.