Succinic acid derivatives

A compound of the general formula (I)

• wherein
• R1 represents a 4- to 9-membered saturated, unsaturated or aromatic cyclic residue,
• which can contain 0 to 3 heteroatoms selected independently from the group N, S and O,
• and wherein R1is substituted by —R1-1—Z,
• wherein
• R1-1 represents a bond, —O—,—S—, NR1-2, C1–C10 alkenyl, C2–C10 alkynyl, C6 or C10 aryl, C3–C7 cycloalkyl or a 4–9-membered saturated or unsaturated heterocyclic residue containing up to 3 heteroatoms selected from the group oxygen, nitrogen and sulfur,
• wherein R1-1can optionally be substituted by 1 to 2 substitutes selected from the group R1-3,
• wherein R1-2can optionally be hydrogen, C1–C10 alkyl, C2–C10 alkenyl or C2–C10 alkynyl, and
• wherein R1-3represents hydrogen, C1–C10 alkyl, C2–C10 alkenyl, C2–C10alkynyl, C6 or C10 aryl, C3–C7 cycloalkyl or a 4–9-membered saturated or unsaturated heterocyclic residue containing up to 3 heteroatoms selected from the group oxygen, nitrogen and sulfur,
• represents —C(O)ORZ-1, —C(O)NRZ-2RZ-3, —SO2NRZ-2RZ-3, —SO(ORZ-1), —SO2(ORZ-1), —P(O)RZ-1(ORZ-3) or —PO(ORZ-1)(ORZ-3),
• wherein Rz-2 is hydrogen, C1–C4 alkyl, C2–C6 alkenyl, C2–C6 alkynyl, C3–C6 cycloalkyl, C6 or C10 aryl, —C(O)Rz-4 or —SO2Rz-4,
• wherein Rz-4 is C1–C4 alkyl, C2–C6 alkenyl, C2–C6 alkynyl, C3–C6 cycloalkyl, C6 or C10 aryl,
• Rz-1 and Rz-3 are independently selected from the group hydrogen, C1–C4 alkyl, C2 –C6 alkenyl, C2 –C6 alkynyl, C3 –C6 cycloalkyl, C6 or C10 aryl and benzyl,
• wherein RZ-1 and RZ-3 can optionally be substituted by 1 to 3 substitutes selected from the group C1–C4 alkyl, C1–C4 alkyloxy, halogen, nitro, and cyano,
• and wherein R1 can optionally be substituted by 0 to 2 substitutes selected from R1-4, halogen, nitro, amino, cyano and oxo,
• wherein
• R1-4 is selected from the group C1–C4 alkyl, C1–C4 alkyloxy, phenyl, phenoxy, phenylamino and C3–C6 cycloalkyl,
• R2 represents hydrogen, C1–C10 alkyl, C2–C10 alkenyl, C2–C1o alkynyl, C6 or C10 aryl or C3–C7 cycloalkyl,
• wherein R2 can optionally be substituted by 1 to 3 radicals independently selected from the group C1C4 alkyl, trifluormethyl, trifluormethoxy, halogen, cyano, nitro and oxo,
• R3 represents hydrogen, C1–C10 alkyl, C2–C10 alkenyl, C2–C10 alkynyl, C6 or C10 aryl, C3–C7 cycloalkyl or a 4–9-membered saturated or unsaturated heterocyclic residue containing up to 2 heteroatoms selected from the group oxygen, nitrogen and sulfur,
• wherein R3 can optionally be substituted by 1 to 3 radicals R3-1,
• wherein R3 represents C1–C4 alkyl, trifluormethyl, trifluormethoxy, —OR3-2, —SR3-2, NR3-3R3-4, —C(O)R3-2, S(O)R3-2, —S)2R3-2, —OC(O)R3-2, —C(O)NR3-3R3-4, —NR3-2C(O)R3-3, —SO2NR3-3R3-4, NR3-2SO2R3-3, —NR3-2C(O)NR3-3R3-4, —NR3-2C(O)OR3-3, —OC(O)NR3-3R3-4, —CO2R3-5, halogen, cyano, nitro or oxo,
• wherein R3-2 represents hydrogen, C1–C4 alkyl, C3–C6 cycloalkyl, C6 or C10 aryl,
• wherein R3-3 and R3-4 are independently selected from the group hydrogen, C1–C4 alkyl, C3–C6 cycloalkyl, C6 or C10 aryl and benzyl,
• and wherein R3-5 represents C1–C4 alkyl, C3–C6 cycloalkyl, C6 or C10 aryl,
• R4 represents hydrogen, C1–C10alkyl, C2–C10 alkenyl, C2–C10 alkynyl, C6 or C10 aryl, C3–C7 cycloalkyl or a 4–9-membered saturated or unsaturated heterocyclic residue containing up to 2 heteroatoms selected from the group oxygen, nitrogen and sulfur,
• wherein R4 can optionally be substituted by 1 to 3 radicals R4-1,
• wherein R4represents C1–C4 alkyl, trifluormethyl, trifluormethoxy, —OR4-2, —SR4-2, NR4-3 R4-1, —C(O)R4-2, S(O)R4-2, —S2R4-2, —OC(O)R4-2, —C(O)NR4R4-4, —NR4-2C(O)R4-3, —S2NR4-3R4-4, NR4-2S2R4-3, —NR4-2C(O)NR4-3R4-4, —NR4-2C(O)OR4-3, —OC(O)NR4-3R4-4, —C2R4-5, halogen, cyano, nitro or oxo,
• wherein R4-2 represents hydrogen, C1–C4 alkyl, C3–C6 cycloalkyl, C6 or C10 aryl,
• wherein R4-3 and R4-4 are independently selected from the group hydrogen, C1–C4 alkyl, C3–C6 cycloalkyl, C6 or C10 aryl and benzyl,
• and wherein R4-5 represents C1–C4 alkyl, C3–C6 cycloalkyl, C6 or C10 aryl or
• R3 and R4 together with the carbon atom to which they are attached form a 4–7-membered saturated or unsaturated ring containing up to 2 heteroatoms selected from the group oxygen, nitrogen and sulfur, which can optionally be substituted by 1 to 2 substitutes selected from the group C1–C4 alkyl, phenyl, benzyl, C3–C7, cycloalkyl, C1–C4 alkyloxy, halogen, nitro, cyano and oxo and which can be fused with a 3–7 membered homocyclic or heterocyclic, saturated, unsaturated or aromatic ring,
• R5 represents hydrogen, C1–C10 alkyl, C2–C10 alkenyl, C2–C10 alkynyl, C6 or C10 aryl or C3–C7, cycloalkyl,
• wherein R5 can optionally be substituted up to threefold by C1–C4 alkyl, trifluormethyl, trifluormethoxy, halogen, cyano, nitro or oxo,
• R6 represents phenyl or a 5- to 6-membered aromatic heterocyclic residue containing up to 3 heteroatoms independently selected from the group oxygen, nitrogen and sulfur,
• wherein R6 is substituted by —NR6-2C(O)NR6-3R or —NR6-2C(S)NR6-3R6-4 and can furthermore optionally be substituted by halogen,
• wherein R6-2 and R6-3 are independently selected from the group hydrogen and C1–C4 alkyl, or together form a group
• and wherein R6-4 represents phenyl,
• wherein R6-4 can optionally be substituted by 1–2 substitutes selected from the group C1–C4 alkyl, C1–C4 alkyloxy, halogen, nitro, trifluormethyl, trifluormethoxy and cyano, or
• R6 represents a group
• wherein R6-1 represents a substituent selected from the group hydrogen, C1–C4 alkyl, C1–C4 alkyloxy, halogen, nitro, trifluormethyl, trifluormethoxy and cyano, and
• wherein R6-5 represents a substituent selected from the group hydrogen, C1–C4 alkyl, C1–C4 alkyloxy, halogen, nitro, trifluormethyl, trifluormethoxy and cyano,
• R7 represents hydrogen, C1–C10 alkyl, C2–C10 alkenyl, C2–C10 alkynyl, C6 or C10 aryl, C3–C7 cycloalkyl or a 4–9-membered saturated or unsaturated heterocyclic residue containing up to 2 heteroatoms selected from the group oxygen, nitrogen and sulfur,
• wherein R7 can optionally be substituted by 1 to 3 radicals R7-1,
• wherein R7-1 represents C1–C4 alkyl, trifluormethyl, trifluormethoxy, —OR7-2, —SR7-2, NR7-3R7-4, —C(O)R7-2, S(O)R7-2, —S2R7-2, —OC(O)R7-2, —C(O)NR7-3R7-4, —NR7-2C(O)R7-3, —S2NR7-3R7-4, NR7-2S2R7-3, —NR7-2C(O)NR7-3R7-4, —NR7-2C(O)OR7-3, —OC(O)NR7-3 R7-4, —C2R7-5, halogen, cyano, nitro or oxo,
• wherein R7-2 represents hydrogen, C1–C4 alkyl, C3–C6 cycloalkyl, C6 or C10 aryl,
• wherein R7-3 and R7-4 are independently selected from the group hydrogen, C1–C4 alkyl, C3–C6 cycloalkyl, C6 or C10 aryl and benzyl,
• and wherein R7-5 represents C1–C4 alkyl, C3–C6 cycloalkyl, C6 or C10 aryl
• R8 represents hydrogen, C1–C10 alkyl, C2–C10 alkenyl, C2–C10 alkynyl, C6 or C10 aryl, C3–C7 cycloalkyl or a 4–9-membered saturated or unsaturated heterocyclic residue containing up to 2 heteroatoms selected from the group oxygen, nitrogen and sulfur,
• wherein R8 can optionally be substituted by 1 to 3 radicals R8-1,
• wherein R8-1 represents C1–C4 alkyl, trifluormethyl, trifluormethoxy, —OR8-2, —SR8-2, NR8-3R8-4, —C(O)R8-2, S(O)R8-2, —SO2R8-2, —OC(O)R8-2, —C(O)NR8-3R8-4, —NR8-2C(O)R8-3, —SO2NR8-3R8-4, NR8-2SO2R8-3, —NR8-2C(O)NR8-3R8-4, —NR8-2C(O)OR8-3, —OC(O)NR8-3R8-4, —CO2R85, halogen, cyano, nitro or oxo,
• wherein R8-2 represents hydrogen, C1–C4 alkyl, C3–C6 cycloalkyl, C6 or C10 aryl,
• wherein R8-3 and R8-4 are independently selected from the group hydrogen, C1–C4 alkyl, C3–C6 cycloalkyl, C6 or C10 aryl and benzyl,
• and wherein R8-5 represents C1–C4 alkyl, C3–C6 cycloalkyl, C6 or C10 aryl or
• R7 and R8 together form a 4–7-membered saturated or unsaturated ring containing up to 2 heteroatoms selected from the group oxygen, nitrogen and sulfur, which can optionally be substituted by 1 to 2 substitutes selected from the group C1–C4 alkyl, phenyl, benzyl, C3–C7 cycloalkyl, C1–C4 alkyloxy, halogen, nitro, cyano, and oxo and which can be fused with a 3–7 membered homocyclic or heterocyclic, saturated, unsaturated or aromatic ring,
• X represents a bond or (—CRZ-1RX-2—)n,
• wherein RX-1 and RX-2 can be independently selected from the group hydrogen, C1–C4 alkyl, C2–C4 alkenyl, and C2–C4 alkynyl,
• wherein RX-1 and RX-2 can optionally independently be substituted by 1 to 2 substitutes selected from the group C1–C4 alkyl, phenyl, benzyl, C3–C7 cycloalkyl, C1–C4 alkyloxy, halogen, nitro, cyano, and oxo,
• and wherein n is an integer 0 or 1,
• or a pharmaceutically acceptable salt thereof.