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US 7,064,219 B2Granted
Processes of producing glutamic acid compounds and production intermediates therefore and novel intermediate for the processes
AssigneeAjinomoto Co., Inc.
InventorsShigeru Kawahara, Yusuke Amino, Kenichi Mori, Nao Funakoshi, Tadashi Takemoto
Life of this patent
Estimating the term…
Abstract
The present invention relates to processes of producing glutamic acid compounds, for example, monatin, which are useful as, for example, production intermediates for sweetener or pharmaceutical products.
Claims10
A process of producing monatin represented by the formula (7′) or a salt thereof:
- comprising:
- aldol reacting an indole-3-pyruvic acid represented by the formula (1′) or a salt thereof and an oxalacetic acid represented by the formula (2) or a salt thereof and decarboxylating:
- or cross aldol reacting an indole-3-pyruvic acid represented by the formula (1′) or a salt thereof and a pyruvic acid represented by the formula (2′) or a salt thereof:
- to obtain a 4-hydroxy-4-(3-indolylmethyl)-2-ketoglutaric acid represented by the formula (4′) or a salt thereof:
- and
- converting the carbonyl group of the ketoglutaric acid represented by the formula (4′) or a salt thereof to an amino group.
3 more elements
Dependencies are inferred from the claim text.