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US 7,064,211 B2Granted
Hemiasterlin derivatives and uses thereof
AssigneeEisai Co., Ltd.
InventorsJames J. Kowalczyk, Galina Kuznetsov, Shawn Schiller, Boris M. Seletsky, Mark Spyvee, Hu Yang
Life of this patent
Estimating the term…
Abstract
The present invention provides compounds having formula (I): and additionally provides methods for the synthesis thereof and methods for the use thereof in the treatment of cancer, wherein R1–R7, X1, X2, R, Q, and n are as defined herein.
Claims18
An intermediate having the structure:
- wherein g is 2;
- L is CRL1RL2, wherein each occurrence of RL1, RL2 and RL3 is independently hydrogen or an aliphatic, alicyclc, heteroaliphatic, heteroalicyclic, aryl or heteroaryl moiety;
- each occurrence of RG1, RM1 and RM2 is each independently hydrogen or an aliphatic, alicyclic or aryl moiety;
- and
- wherein any two adjacent RL1, RL2, RL3, RG1, RM1 or RM2 groups, taken together, form a
- R2 is hydrogen or an aliphatic, alicyclic or aryl moiety;
- and
- R6 is hydrogen or an aliphatic, alicycluc or aryl moiety.
5 more elements
An intermediate having the structure:
- wherein Rx1 and Rx2 are independently hydrodrogen, aliphatic, alicyclic or aryl;
- L is CRL1RL2, wherein each occurrence of RL1, RL2 and RL3 is independently hydrogen or an aliphatic, alicycic, heteroaliphatic, heteroalicyclic, aryl or heteroaryl moiety;
- each occurrence of RG1, RM1 and RM2 is each independently hydrogen or an aliphatic, alicyclic or aryl moiety;
- and
- R2 is hydrogen or an aliphatic, alicyclic or aryl moiety;
- and
- R6 is hydrogen or an aliphatic, alicyclic or aryl moiety.
4 more elements
Dependencies are inferred from the claim text.