Back to results
US 7,064,205 B2Granted
Process for preparing 1-methoxymethyl-5,5-diphenylbarbituric acid
AssigneeTaro Pharmaceutical Industries Ltd.
InventorsDaniella Gutman, Rosa Cyjon
Life of this patent
Estimating the term…
Abstract
The present invention provides a novel process for preparing 1-methoxymethyl-5,5-diphenylbarbituric acid. In particular, the present invention provides a process for preparing 1-methoxymethyl-5,5-diphenylbarbituric acid by reacting 1,3-bis(methoxymethyl)-5,5-diphenylbarbituric acid with a Lewis acid to selectively remove one methoxymethyl group from 1,3-bis(methoxymethyl)-5,5-diphenylbarbituric acid.
Claims22
A process for preparing 1-methoxymethyl-5,5-diphenylbarbituric acid comprising the steps of:
- (a) reacting 1,3-bis(methoxymethyl)-5,5-diphenylbarbituric acid with about 0.2 to about 2 equivalents of aluminum chloride at a temperature of about 70° C. to about 130° C., for about one to about five hours;
- and
- (b) isolating the 1-methoxymethyl-5,5-diphenylbarbituric acid.
Dependencies are inferred from the claim text.