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US 7,064,203 B2Granted
Di-substituted pyrrolotriazine compounds
AssigneeBristol-Myers Squibb Company
InventorsAshvinikumar V. Gavai, Wen-Ching Han, Ping Chen, Edward H. Ruediger, Harold Mastalerz, Brian E. Fink, Derek J. Norris
Life of this patent
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Abstract
The present invention provides compounds of formula I and pharmaceutically acceptable salts thereof. The compounds of the invention inhibit tyrosine kinase activity of growth factor receptors such as HER1, HER2 and HER4 thereby making them useful as antiproliferative agents for the treatment of cancer and other diseases.
Claims6
A compound of formula I
- wherein the symbols have the following meanings and are, for each occurrence, independently selected:
- R1 and R2 are independently aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocyclo or substituted heterocyclo;
- R3 and R4 are independently hydrogen, alkyl, substituted alkyl, halogen, alkoxy, substituted alkoxy, aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocyclo, substituted heterocyclo, alkylheterocyclo, substituted alkylheterocyclo, —O-heterocyclo or —NHCOOalkylheterocyclo;
- R5 and R5a are hydrogen, alkyl, substituted alkyl or halogen,
- X is —O— or NR5;
- n is 1 or 2;
- or a pharmaceutically acceptable salt or stereoisomer thereof.
4 more elements
Dependencies are inferred from the claim text.