Camptothecin intermediates and prodrugs and methods of preparation thereof

A compound with the formula:

• where R1 may be:
• a) hydrogen, a halogen atom, a branched or linear alkyl group, a branched or linear alkenyl group, a branched or linear alkynyl group, a cycloalkyl group, a cycloalkenyl group, an alkoxy group, an alkylamino group, a dialkylamino group, an alkylthiol group, a thiol group, a phenyl group, an amino group, a nitro group, a cyano group;
• b) a (CH2)YNR8R9 group, wherein Y is an integer from 1–10 and R8 and R9 are, independently, hydrogen, an alkyl group, an alkenyl group, an alkynyl group, an amine, an alkyl amine, a dialkyl amine, a hydroxy group, an alkoxy group, an acyl group, a carbamate;
• R2 may be:
• a) hydrogen, a halogen atom, a linear or branched alkyl group, a linear or branched alkenyl group, a linear or branched alkynyl group, an amino group, an alkylamino group, a dialkylamino group, a nitro group, a 3–10 membered heterocyclic ring, a C3-10 cycloalkyl group, a C3-10 cycloalkenyl group, a C8-10 cycloalkynyl group, a thiol group, a cyano group;
• b) a (CH2)YNR8R9 group, wherein Y is an integer from 1–10 and R8 and R9 are, independently, hydrogen, an alkyl group, an alkenyl group, an alkynyl group, an amine, an alkyl amine, a dialkyl amine, a hydroxy group, an alkoxy group, an acyl group, a carbamate;
• R3 may be:
• a) hydrogen, a halogen atom, a linear or branched alkyl group, a linear or branched alkenyl group, a linear or branched alkynyl group, an amino group, an alkylamino group, a dialkylamino group, a nitro group, a 3–10 membered heterocyclic ring, a C3-10 cycloalkyl group, a C3-10 cycloalkenyl group, a C8-10 cycloalkynyl group, a thiol group, a cyano group, a hydroxyl group;
• b) a (CH2)YNR8R9 group, wherein Y is an integer from 1–10 and R8 and R9 are, independently, hydrogen, an alkyl group, an alkenyl group, an alkynyl group, an amine, an alkyl amine, a dialkyl amine, a hydroxy group, an alkoxy group, an acyl group, a carbamate;
• R4 may be hydrogen, a halogen atom, a hydroxy group, an amino group, a methoxy group, an alkyl group, an alkynyl group or an alkenyl group;
• R5 may be hydrogen or fluorine;
• R6 may be an alkyl group, an alkenyl group, an alkynyl group, a benzyl group, an alkoxy group, an aryloxy group, or an acyloxy group;
• R7 may be hydrogen, an alkyl group, an alkenyl group, a benzyl group, an alkoxy group, an aryloxy group, or an acyloxy group;
• and
• R8 may be hydrogen, an alkyl group, or an alkenyl group;
• and
• pharmaceutically acceptable salts thereof.