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US 7,064,200 B2Granted
Process for the synthesis of 1,3,4,5-tetrahydro-2H-3-benzazepin-2-one compounds, and application in the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid
AssigneeLes Laboratoires Servier
InventorsJean-Michel Lerestif, Jean-Pierre Lecouve, Jean-Claude Souvie, Daniel Brigot
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Abstract
Process for the synthesis of compounds of formula (I): wherein R1 and R2, which may be the same or different, each represent a linear or branched (C1–C8)alkoxy group or form, together with the carbon atom carrying them, a 1,3-dioxane, 1,3-dioxolane or 1,3-dioxepane ring. Application in the synthesis of ivabradine, addition salts thereof with a pharmaceutically acceptable acid, and hydrates thereof.
Claims11
A process for the synthesis of compounds of formula (I):
- wherein R1 and R2, which may be the same or different, each represent linear or branched (C1–C8)alkoxy or form, together with the carbon atom carrying them, a 1,3-dioxane, 1,3-dioxolane or 1,3-dioxepane ring,
- wherein a compound of formula (VI):
- is subjected to a catalytic hydrogenation reaction,
- in a non-acidic solvent,
- and then the reaction mixture is filtered
- to yield the compound of formula (I).
3 more elements
A compound selected from those of formula (I):
- wherein R1 and R2, which may be the same or different, each represent linear or branched (C1–C8)alkoxy or form, together with the carbon atom carrying them, a 1,3-dioxane, 1,3-dioxolane or 1,3-dioxepane ring.
Dependencies are inferred from the claim text.