Therapeutic molecules
AssigneeThe Walter and Eliza Hall Institute of Medical Research
InventorsSuzanne Cory, Jerry Adams, David C. S. Huang, Liam O'Connor, Andreas Strasser, Hamsa Puthalakath, Lorraine O'Reilly
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Abstract
The present invention relates generally to novel molecules capable of, inter alia, modulating apoptosis in mammalian cells and to genetic sequences encoding same. More particularly, the present invention relates to a novel member of the Bcl-2 family of proteins, referred to herein as “Bim”, and to genetic sequences encoding same. The molecules of the present invention are useful, for example, in therapy, diagnosis, antibody generation and as a screening tool for therapeutic agents capable of modulating physiological cell death or survival and/or modulating cell cycle entry.
Claims7
An isolated nucleic acid molecule comprising a nucleotide sequence encoding or complementary to a sequence encoding an amino acid sequence comprising SEQ ID NO:10 or having at least about 89% or greater identity to SEQ ID NO:10 wherein said amino acid sequence induces apoptosis.
An isolated nucleic acid molecule comprising SEQ ID NO:9.
An isolated polypeptide comprising SEQ ID NO:10 or a sequence having at least about 89% identity to SEQ ID NO:10 wherein said polypeptide induces apoptosis.
Dependencies are inferred from the claim text.