Substantially non-immunogenic injectable collagen
AssigneeCrossCart, Inc.
InventorKevin R. Stone
Life of this patent
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Abstract
The invention provides an article of manufacture comprising a substantially non-immunogenic injectable collagen for implantation into humans. The invention further provides methods for preparing injectable collagen material by removing collagen-containing material from a non-human animal; washing in saline and alcohol; subjecting material to cellular disruption treatment; and digesting the material with a proteoglycan-depleting factor and/or glycosidase and optionally following with a capping treatment. The invention also provides an article of manufacture produced by the method. The injectable collagen material of the invention are substantially non-immunogenic and have substantially the same mechanical properties as a corresponding native soft tissue.
Claims14
A method of preparing a collagen-containing material for injection into a human, comprising:
- A. removing at least a portion of a collagen-containing material from a non-human animal;
- B. subjecting the collagen-containing material to a cellular disruption treatment;
- C. digesting the collagen-containing material with a glycosidase to remove first surface carbohydrate moieties;
- and
- D. establishing said collagen-containing material in a form of a liquid, colloid, semi-solid, suspended particulate, gel, or paste, and combinations thereof.
A method of preparing a collagen-containing material for injection into a human, comprising:
- A. removing at least a portion of a collagen-containing material from a non-human animal;
- B. subjecting the collagen-containing material to a cellular disruption treatment;
- C. treating said collagen-containing material with proteoglycan depleting factors to establish said collagen-containing material as having reduced proteoglycans;
- and
- D. establishing said collagen-containing material in a form of a liquid, colloid, semi-solid, suspended particulate, gel, or paste, and combinations thereof.
Dependencies are inferred from the claim text.