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US 7,064,147 B2Granted
Amino acids with affinity for the α-2-delta-protein
AssigneeWarner-Lambert Company
InventorsNancy Sue Barta, Jacob Bradley Schwarz, Andrew John Thorpe, David Juergen Wustrow
Life of this patent
Estimating the term…
Abstract
This invention relates to certain β-amino acids that bind to the alpha-2-delta (α2δ) subunit of a calcium channel. These compounds and their pharmaceutically acceptable salts are useful in the treatment of a variety of psychiatric, pain and other disorders.
Claims8
A compound having the formula IA
- or a pharmaceutically acceptable salt thereof;
- wherein R1 is hydrogen or (C1–C3)alkyl optionally substituted with from one to five fluorine atoms;
- R2 is hydrogen or (C1–C3)alkyl optionally substituted with from one to five fluorine atoms;
- and
- R3 is (C1–C6)alkyl optionally substituted with from one to five fluorine atoms;
- with the proviso that when R1 is hydrogen, R2 is not hydrogen.
3 more elements
A compound selected from 3-amino-5-methyl-octanoic acid and pharmaceutically acceptable salts thereof.
A compound selected from (3S5R)-3-amino-5-methyl-octanoic acid and pharmaceutically acceptable salts thereof.
Dependencies are inferred from the claim text.