Inhibition of beta cell degeneration
AssigneeNovo Nordisk A/S
InventorRichard David Carr
Life of this patent
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Abstract
Methods for preventing beta cell degeneration, such as necrosis or apoptosis of beta cells in a subject, comprising administering a DPP-IV inhibitor to a subject in need thereof. The invention furthermore relates to a method for increasing the number and/or the size of beta cells. The invention also relates to a method for delaying the progression of Impaired Glucose Tolerance (IGT) to type 2 diabetes, as well as a method for delaying the progression of non-insulin demanding type 2 diabetes to insulin-demanding type 2 diabetes.
Claims23
A method of inhibiting beta cell degeneration in a subject suffering from loss of beta cell function, beta cell dysfunction, necrosis or apoptosis of beta cells, said method comprising administering a DPP-IV inhibitor to said subject, wherein the DPP-IV inhibitor is selected from N-substituted adamantyl-amino-acetyl-2-cyano pyrrolidine or N-(substituted glycyl)-4-cyano pyrrolidine.
A method of increasing beta cell population size in a subject suffering from a decrease in the number of beta cells in its beta cell population, said method comprising administering a DPP-IV inhibitor to said subject, wherein the DPP-IV inhibitor is selected from N-substituted adamantyl-amino-acetyl-2-cyano pyrrolidine or N-(substituted glycyl)-4-cyano pyrrolidine.
A method of increasing individual beta cell size in a subject suffering from a decrease in individual beta cells size, said method comprising administering a DPP-IV inhibitor to said subject, wherein the DPP-IV inhibitor is selected from N-substituted adamantyl-amino-acetyl-2-cyano pyrrolidine or N-(substituted glycyl)-4-cyano pyrrolidine.
A method of delaying the progression of Impaired Glucose Tolerance to type 2 diabetes in a subject suffering from Impaired Glucose Tolerance in need of such treatment, said method comprising administering a DPP-IV inhibitor to said subject, wherein the DPP-IV inhibitor is selected from N-substituted adamantyl-amino-acetyl-2-cyano pyrrolidine or N-(substituted glycyl)-4-cyano pyrrolidine.
A method of delaying the progression of Impaired Fasting Glucose to type 2 diabetes in a subject suffering from impaired Fasting Glucose in need of such treatment, said method comprising administering a DPP-IV inhibitor to said subject, wherein the DPP-IV inhibitor is selected from N-substituted adamantyl-amino-acetyl-2-cyano pyrrolidine or N-(substituted glycyl)-4-cyano pyrrolidine.
A method for delaying the progression of non-insulin demanding type 2 diabetes to insulin-demanding type 2 diabetes in a subject suffering from non-insulin demanding type 2 diabetes in need of such treatment, said method comprising administering a DPP-IV inhibitor to said subject, wherein the DPP-IV inhibitor is selected from N-substituted adamantyl-amino-acetyl-2-cyano pyrrolidine or N-(substituted glycyl)-4-cyano pyrrolidine.
Dependencies are inferred from the claim text.