Imidazole derivatives as adenosine deaminase inhibitors
AssigneeAstellas Pharma Inc.
InventorsTadashi Terasaka, Takeshi Kato, Kiyoshi Tsuji, Katsuya Nakamura
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Abstract
Imidazole compounds having adenosine deaminase inhibitory activity represented by the formula (I) wherein R1 is aryl or heterocyclic group which is optionally substituted with substituent(s); R2 is lower alkyl; R3 is hydroxy or protected hydroxy; -A- is lower alkylene; and —X— is —O— or —S—; provided that when then R1 is aryl which is substituted with substituent(s), or heterocyclic group which is optionally substituted with substituent(s), its prodrug, or their salt. The compounds are useful for treating and/or preventing diseases for which adenosine is effective.
Claims12
A compound of the formula
- wherein R1 is aryl or heterocyclic group which is optionally substituted with substituent(s);
- R2 is lower alkyl;
- R3 is hydroxy or protected hydroxy;
- —A— is lower alkylene;
- and
- —X— is —O— or —S—;
- provided that when —X— is —O—, then R1 is aryl which is substituted with substituent(s), or heterocyclic group which is optionally substituted with substituent(s),
- or a salt thereof.
Dependencies are inferred from the claim text.