Synergistic combinations including N-acylated 4-Hydroxyphenylamine derivatives and caffeine
OwnerCarlos Sunkel, Nicolas G. Bazan +2inventors
InventorsCarlos Sunkel, Nicolas G. Bazan, Dennis Paul, Julio Alvarez-Builla
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Abstract
The present invention relates to pharmaceutical combinations of opioid and non-opioid analgesics in an intimate admixture with caffeine and an analgesic from a series of N-acylated 4-hydroxyphenylamine derivatives, linked via an alkylene bridge to the nitrogen atom of a 1,2-benzisothiazol-3(2H)-one 1,1-dioxide group and methods for their use to alleviate pain in mammals. The analgesic combinations exhibit enhanced analgesic potency and are free from antipyretic activity, do not suppress blood coagulation, and have little hepatotoxic effect.
Claims36
An analgesic composition comprising synergistic, safe, and pharmaceutically effective amounts of:
- (a) an opioid analgesic;
- (b) a non-narcotic analgesic of the general formula,
- wherein n is a number from 1 to 5;
- (c) caffeine;
- and
- (d) a pharmaceutically acceptable carrier.
An analgesic composition comprising synergistic, safe, and pharmaceutically effective amounts of:
- (a) a non-opioid analgesic;
- (b) a non-narcotic analgesic of the general formula,
- wherein n is a number from 1 to 5;
- (c) caffeine;
- and
- (d) a pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.