Compounds

A compound having the formula

• wherein:
• R1 is C1-4alkyl, substituted by 1 or 2 substituents selected from —NRaRa, —NRaC(═O)Ra, —C(═O)NRaRa, —ORa, —OC(═O)Ra, —C(═O)ORa, —S(═O)nC1-6alkyl, nitro, cyano and C1-3haloalkyl;
• phenyl substituted by 0, 1, 2 or 3 substituents selected from —NRaRa, —NRaC(═O)Ra, —C(═O)NRaRa, —ORa, —OC(═O)Ra, —C(═O)ORa, —S(═O)nC1-6alkyl, nitro, cyano and C1-3haloalkyl;
• or a 5- or 6-membered ring heterocycle containing 1, 2 or 3 heteroatoms each independently selected from O, N and S and additionally having 0 or 1 oxo groups and 0 or 1 fused benzo rings;
• R2 is H, halogen, —OR9 or C1-4alkyl;
• R3 is H, halogen, —OR9 or —CN;
• R4 is H, halogen, —OR9 or C1-4alkyl;
• R5 is H or CH3;
• R7 is phenyl substituted by 0, 1, 2 or 3 substituents selected from C1-6alkyl, —NRaRa, —NRaC(═O)Ra, —C(═O)NRaRa, —ORa, —OC(═O)Ra, —C(═O)Ra, —C(═O)ORa, —S(═O)nC1-6alkyl, nitro, cyano, C1-3haloalkyl, trifluoromethylthio, trifluoromethylsulfinyl, C1-6alkanesulfonamido, succinamido, carbamoyl, C1-6alkylcarbamoyl, di-C1-6alkylcarbamoyl, C1-6alkoxy-C1-6alkylcarbamoyl, ureido, C1-6alkylureido, di(C1-6alkyl)ureido, bromo, fluoro, chloro and dimethylcarbamoylmethylureido;
• or
• R7 is a 5- or 6-membered ring heterocycle containing 1, 2 or 3 heteroatoms each independently selected from O, N and S, said heterocycle additionally having 0 or 1 oxo groups and being substituted by 0 or 1 substituents selected from —ORa, —OC(═O)Ra, —C(═O)ORa, —C(═O)Ra, —NRaRa, —NRaC(═O)Ra and —C(═O)NRaRa;
• or
• R7 is hydrogen or NRaRa;
• R8 is selected from hydrogen, —ORa, —OC(═O)Ra, —C(═O)ORa, —C(═O)Ra, —NRaRa, —NRaC(═O)Ra, —C(═O)NRaRa, C1-6alkyl, carbamoyl, C1-6alkylcarbamoyl, and bis(C1-6alkyl)carbamoyl;
• Ra is independently at each instance hydrogen or C1-6alkyl;
• R9 is C1-6alkyl, phenyl or phenylC1-6alkyl;
• n is 0, 1 or 2;
• and
• X1 and X2 are independently H, —CH3 or halogen;
• or
• any pharmaceutically-acceptable salt thereof.