Preferentially substituted calcium channel blockers

A pharmaceutical composition for use in treating pain which composition comprises, in admixture with a pharmaceutically acceptable excipient, a dosage amount of at least one compound of the formula

• or salts thereof,
• wherein Cy represents cyclohexyl and Φ represents phenyl;
• Y is CH═CHΦ or Φ,
• X is trivalent straight-chain alkylene (3–10C) or trivalent straight-chain 1-alkenylene (3–10C) optionally substituted by oxo at the C adjacent N when n is 0 and Y is CHΦ2;
• and is otherwise trivalent straight-chain alkylene (5–10C) or trivalent straight-chain 1-alkenylene (5–10C) optionally substituted by oxo at the C adjacent N;
• Z is N or CHNR1, wherein R1 is alkyl (1–6C);
• and
• n is 0–5;
• wherein each Φ and Cy independently may optionally be substituted by alkyl (1–6C) or by halo, CF3, OCF3, NO2, NR2, OR, SR, COR, COOR, CONR2, NROCR or OOCR where R is H or alkyl (1–4C), or two substituents may form a 5–7 membered ring
• with the proviso that the compounds of formula (1) contain at least one aromatic moiety.