LPAAT-β inhibitors and uses thereof

A method for inhibiting LPAAT-β (lysophosphatidic acid acyltransferase β) comprising contacting LPAAT-β with an effective amount of a compound of the Formula:

• wherein,
• R1 is halo, hydroxy, alkylmercapto, mercapto, alkoxy, aryloxy or —NRR wherein each R group is independently selected from hydrogen, alkyl, substituted alkyl, cycloalkyl, aryl, or the R groups are joined together to form a heterocyclic ring with the N;
• R2, R3, R4 and R5, each of which may be same or different, are hydrogen, alkyl, substituted alkyl, alkenyl, alkynyl, aryl or aryl substituted with 1 to 3 substituents selected from hydroxy, alkoxy and halogen;
• or
• R2 and R3 or R4 and R5, together with the nitrogen to which they are attached, form a piperidine, piperazine, or a morpholine ring;
• or
• pharmaceutically acceptable salt thereof;
• thereby inhibiting LPAAT-β.