Tricyclic pyridyl carboxamides and derivatives thereof tocolytic oxytocin receptor antagonists

A compound of the formula:

• wherein:
• R1 and R2 are, independently, selected from hydrogen, (C1–C6)lower alkyl, halogen, cyano, trifluoromethyl, hydroxy, amino, (C1–C6) lower alkylamino, (C1–C6) lower alkoxy, —OCF3, (C1–C6) lower alkoxy carbonyl, —NHCO[(C1–C6)lower alkyl], carboxy, —CONH2, —CONH[(C1–C6) lower alkyl], or —CON[(C1–C6) lower alkyl]2;
• R3 is a substituent selected from hydrogen, (C1–C6) lower alkyl, (C1–C6) lower alkoxy, hydroxy, amino, (C1–C6) lower alkylamino, CO lower alkyl (C1–C6), or halogen;
• R4 is the moiety B–C;
• wherein:
• B is selected from the group of:
• and C is selected from the group of:
• wherein:
• A is CH or N;
• R5, R6, R7, R8, R9, R10 are, independently, selected from hydrogen, (C1–C6) lower alkyl, (C1–C6) lower alkoxy, (C1–C6) lower alkylcarbonyl, (C3–C6) lower alkenyl, (C3–C6) lower alkynyl, (C3–C8) cycloalkyl, formyl, cycloalkylcarbonyl, carboxy, alkoxycarbonyl, cycloalkyloxycarbonyl, aryl alkyloxycarbonyl, carbamoyl, —O—CH2—CH═CH2, halogen, halo lower alkyl, trifluoromethyl, OCF3, S(lower alkyl), —OC(O)N[lower alkyl]2, —CONH[lower alkyl], —CON[lower alkyl]2, lower alkylamino, di-lower alkylamino, lower alkyl di-lower alkylamino, hydroxy, cyano, trifluoromethylthio, nitro, amino, lower alkylsulfonyl, aminosulfonyl, lower alkylaminosulfonyl,
• phenyl or naphthyl;
• R11 and R12 are, independently, selected from the group of hydrogen, (C1–C6) lower alkyl, (C2–C6) lower alkenyl, (C3–C6) lower alkynyl, hydroxy (C1–C6) lower alkyl, alkoxy (C1–C6) lower alkyl, acyloxy (C1–C6) lower alkyl, cyclo lower alkyl, or aryl, optionally substituted by hydroxy, (C1–C6) lower alkoxy, halogen, cyano, SO2[(C1–C6) lower alkyl], or —S[(C1–C6) lower alkyl];
• and R is selected from the groups:
• wherein:
• R13 is selected from hydrogen, (C1–C6) lower alkyl, cyanoethyl or
• R14 is selected from hydrogen or (C1–C6) lower alkyl;
• R15 is one or two substituents selected from the group of hydrogen, (C1–C6) lower alkyl, halogen, trifluoromethyl, (C1–C6) lower alkoxy, (C1–C6) lower alkoxycarbonyl, or
• R16 represents one to two substituents selected from hydrogen, or (C1–C6) lower alkyl;
• m is an integer from 0 to 2;
• n is an integer from 1 to 2;
• and p is an integer from 0 to 1;
• or a pharmaceutically acceptable salt form thereof.