Anti-cancer 2,3-dihydro-1H-pyrrolo[3,2-f]quinoline complexes of cobalt and chromium

An 8-quinoline metal complex represented by Formula I

• wherein:
• X is halogen, and
• R is formula VI or VII
• wherein each T1, T2, and T3 is independently OR5, NR52, NHCOR5, or O(CH2)nNR52, where each R5 independently represents H, a C1-6 alkyl optionally substituted with one or more hydroxy or amino groups, and each n is independently 1, 2, 3, or 4, and
• • represents the point of attachment of R to Formula I defined above, and
• wherein ligands L1–L4 represent one of the tetradentate ligands IX or X
• wherein each R1′ to R4′ independently represents H, Me, CH2(CH2)nSO3H, CH2(CH2)nCO2H, CH2(CH2)nOP(O)(OH)2, or CH2(CH2)nNMe2, where each n is independently 1, 2, 3, or 4, each Z is independently —(CH2)2— or —(CH2)3—, and
• wherein the overall charge of the complex is neutral, positive, or negative and wherein in the case of a non-neutral complex Fcountercharge is selected from a range of physiologically acceptable counterions, including halide−, NO3−, NH4−, or Na+, and wherein q is the required number to neutralize the overall charge on the complex;
• or an enantiomer, a diastereomer or a physiologically functional salt thereof.