Gel-microemulsion formulations

A spermicidal composition comprising a gel-microemulsion comprising an oil-in-water microemulsion and a polymeric hydrogel, wherein the oil-in-water microemulsion comprises:

• a lipid comprising a fatty acid glyceride ester;
• one or more pharmaceutically acceptable surfactants;
• one or more pharmaceutically acceptable humectants;
• and
• water.

A spermicidal composition comprising a gel-microemulsion comprising:

• an oil-in-water microemulsion, wherein the oil-in-water microemulsion comprises
• a lipid;
• one or more pharmaceutically acceptable surfactants;
• one or more pharmaceutically acceptable humectants;
• and
• water;
• and a polymeric hydrogel selected from the group consisting of
• natural gel-forming polymers selected from the group consisting of carrageenan, xanthan gum, gum karaya, gum acacia, locust bean gum, and guar gum;
• and
• synthetic gel-forming polymers.

A spermicidal composition comprising a gel-microemulsion comprising an oil-in-water microemulsion and a polymeric hydrogel, wherein the oil-in-water microemulsion comprises:

• a lipid;
• one or more pharmaceutically acceptable surfactants, wherein the surfactant comprises one or more non-ionic surfactants;
• one or more pharamaceuticaily acceptable humectants;
• water;
• and
• one or more preservatives selected from the group consisting of sodium benzoate, methyl parabens, propyl parabens, thimerisal, and sorbic acid.

A spermicidal composition comprising a gel-microemulsion comprising an oil-in-water microemulsion and a polymeric hydrogel, wherein the oil-in-water microemulsion comprises:

• a lipid;
• one or more pharmaceutically acceptable surfactants;
• one or more pharmaceutically acceptable humectants;
• and water,
• wherein the composition has a viscosity in the range of about 200 to about 1000 centipoise.

A spermicidal composition comprising a gel-microemulsion comprising an oil-in-water microemulsion and a polymeric hydrogel, wherein the oil-in-water microemulsion comprises:

• a lipid;
• one or more pharmaceutically acceptable surfactants;
• one or more pharmaceutically acceptable humectants;
• and water,
• wherein the composition has a submicron particle size in the range of about 30 to about 80 nm.

A spermicidal composition comprising a gel-microemulsion comprising an oil-in-water microemulsion and about 0.5% to about 4% by weight of polymeric hydrogel, wherein the oil-in-water microemulsion comprises:

• about 2% to about 25% by weight lipid;
• about 3% to about 30% by weight surfactant of one or more pharmaceutically acceptable surfactants;
• about 2% to about 24% of one or more pharmaceutically acceptable humectants;
• and water;
• about 0% to about 0.5% preservative.

A spermicidal composition comprising a gel-microemulsion comprising an oil-in-water microemulsion and about 1% to about 2% by weight of natural polymer gel, wherein the oil-in-water microemulsion comprises:

• in the range of about 6% to about 23% medium chain C6-C12 triglyceride;
• in the range of about 3% to about 10% ethoxylated castor oil;
• in the range of about 1.5% to about 6% phospholipid;
• in the range of about 1.5% to about 6% propylene glycol;
• in the range of about 1.5% to about 6% polyethylene glycol;
• and water;
• and about 0% to about 0.2% preservative.

A spermicidal composition comprising a gel-microemulsion comprising an oil-in-water microemulsion and about 0.6% to about 2% by weight of natural polymer gel, wherein the composition comprises:

• in the range of about 2% to about 20% medium chain C6-C12 triglyceride;
• in the range of about 1% to about 10% ethoxylated castor oil;
• in the range of about 0.2% to about 1% block copolymer of ethylene oxide and propylene oxide;
• in the range of about 1% to about 10% phospholipid;
• in the range of about 2% to about 22% propylene glycol;
• and
• in the range of about 0% to about 0.3% preservative.