Use of soluble costimulatory factor for tumor immuno-gene therapy
AssigneeGeorgetown University
InventorsTomoki Todo, Samuel D. Rabkin, Robert L. Martuza
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Abstract
A new gene therapy entails tumor treatment by introducing an expressible nucleotide sequence for a soluble costimulatory factor, thereby enhancing the response of T-cells to a tumor. In vivo expression of the soluble factor overcomes anergy or tolerance to tumor cells and activates T-cells that are infiltrating or surrounding the tumor. A pharmaceutical composition containing such a gene is effective in tumor suppression.
Claims16
A method of activating or enhancing a T-cell response in a patient with a tumor, comprising administering to said patient, via localized delivery, a pharmaceutical composition comprising a herpes simplex virus vector comprising an expressible nucleotide sequence for a soluble costimulatory factor in the B7 family, which factor is selected from the group consisting of B7-1-Ig and B7-2-Ig, such that (i) said factor is expressed by tumor cells or cells in the immediate area of the tumor, and (ii) said T-cell response thereby is activated or enhanced against said tumor.
A pharmaceutical composition comprising (A) a herpes simplex virus vector that contains a gene encoding a soluble costimulatory factor in the B7 family, which factor is selected from the group consisting of B7-1-Ig and B7-2-Ig, and (B) a pharmaceutically compatible carrier.
Dependencies are inferred from the claim text.