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AssigneeLaboratories Thea
InventorsJacques Luyckx, Frederic Pilotaz
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The invention relates to a pharmaceutical composition for preventing and/or treating eye infections, which is to be used by local application. It is in particular directed towards such a composition which is in the form of an eye lotion which can be distributed by drops, in which an antibiotic of the macrolide class, such as azithromycin, is in solution in an oily vehicle. This vehicle is, in particular, of the type of product essentially consisting of medium-chain triglycerides in which the alcohol functions of the glycerol are entirely esterified by carboxylic acids made from saturated hydrocarbons, the molecule of which comprises from 5 to 12 carbon atoms. They are preferably linear-chain fatty acids comprising from 8 to 10 carbon atoms, such as caprylic acid or capric acid. The composition is advantageously prepared by dissolving the active agent in the oily vehicle at a temperature not exceeding 70° C.
A pharmaceutical composition in an eye dropper for treating eye infections by local application, which is in the form of an eye lotion contained in an eye dropper, the eye lotion containing a therapeutically active content of an antibiotic macrolide compound dissolved as a true solution or as a solution that can contain particles of not more than 0.2 microns in a physiologically compatible oily vehicle of fatty acid triglycerides.
A pharmaceutical composition for treating eye infections by local application, which is in the form of an eye lotion and comprises a therapeutically active content of azithromycin as a true solution or as a solution that can contain particles of not more than 0.2 microns within an oily vehicle made of physiologically compatible triglycerides essentially selected from triglycerides of carboxylic acids of linear-chained saturated hydrocarbons.
A pharmaceutical composition in the form of an eye lotion comprising a therapeutically active content of an azalide and an oily vehicle made of physiologically compatible triglycerides of carboxylic acids of linear-chained saturated hydrocarbons of medium length, wherein the azalide is present at a concentration in the range from 0.7 to 2% by weight of the total composition weight and is in true solution within said vehicle.
A pharmaceutical composition stored in an eye-drop dispenser for treating eye infections by local application, comprising a true solution or as a solution that can contain particles of not more than 0.2 microns of a therapeutically active content of azithromycin in an oily vehicle consisting essentially of triglycerides of carboxylic acids of saturated hydrocarbons with a linear chain of medium length.
In a method for the treatment of eye infections comprising applying onto the eye a pharmaceutical composition, the improvement wherein the pharmaceutical composition is a true solution or as a solution that can contain particles of not more than 0.2 microns of azithromycin in an oily vehicle of fatty acid triglycerides.
In a method for the treatment of eye infections comprising applying to the eye a pharmaceutical composition, the improvement wherein the pharmaceutical composition comprises a true solution or as a solution that can contain particles of not more than 0.2 microns of a therapeutically effective amount of antibiotic macrolide compound dissolved in a physiologically compatible oily liquid vehicle of fatty acid triglycerides.
Dependencies are inferred from the claim text.