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US 7,064,103 B2Granted
Binding protein as biosensors
AssigneeBecton, Dickinson and Company
InventorsJ. Bruce Pitner, Jason E. Gestwicki, Zachary A. Pfieffer, Helen V. Hsieh
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Abstract
The invention is directed to compositions of mutated binding proteins containing thiol groups for coupling to sensor surfaces, analyte biosensor devices derived there from, and methods of their use as analyte biosensors both in vitro and in vivo.
Claims12
A biosensor comprising:
- a) at least one mutated glucose/galactose binding protein having at least one substituted or added cysteine group;
- and
- b) at least one sensor surface wherein said mutated binding protein is coupled through said cysteine group to said surface;
- wherein said at least one sensor surface provides a detectable signal resulting from a change in refractive index when said mutated binding protein binds to analyte.
1 more element
The biosensor of 7 wherein said mutated glucose/galactose binding protein further includes a histidine tag.
Dependencies are inferred from the claim text.