Interface between substrates having microarrays and microtiter plates
AssigneesGrace Bio-Labs, Inc., President and Fellows of Harvard College
InventorsGavin MacBeath, Jennipher Grudzien
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Abstract
The invention describes a process for preparing a microtiter-microarray device that includes a bottomless microtiter plate attached to the first side of one or more substrates with microarrays of materials attached thereto. The microtiter plate and the one or more substrates are attached through one or more gaskets. Preferably, the microtiter plate is attached to one face of the one or more gaskets by an irreversible water-tight seal, and the first side of the one or more substrates is attached to the opposite face of the one or more gaskets by a reversible, water-tight seal.
Claims59
A microtiter-microarray device comprising:
- a bottomless microtiter plate having a plurality of wells;
- one ore more gaskets having a first face, a second face, and a plurality of perforations;
- and
- one or more substrates having a first side with a plurality of predeposited microarrays of materials attached thereto, whereby the wells, the perforations, and the microarrays are arranged in identical patterns, the microtiter plate and the one or more substrates are attached through the one or more gaskets so that the plurality of wells, the plurality of perforations are aligned and sealingly joined to the one or more substrates to form an individual reaction chamber for each microarray.
A method for preparing a microtiter-microarray device comprising:
- providing a bottomless microtiter plate having a plurality of wells;
- providing one or more gaskets having a first, a second face, and a plurality of perforations;
- providing one or more substrates having a first face with a plurality of predeposited microarrays of materials attached thereto;
- providing the wells, the perforations and the microarrays in identical patterns;
- adhering the bottomless microtiter plate to the first face of the one or more gaskets so that the plurality of wells are aligned with the plurality of perforations;
- and
- adhering the first side of the one or more substrates to the second face of the one or more gaskets so that the plurality of microarrays are aligned with the plurality of perforations.
Dependencies are inferred from the claim text.