Yeast-based process for production of l-pac
AssigneesVictoria University of Technology, Polychip Pharmaceuticals Pty Ltd
InventorsAndrew John Smallridge, Maurice Arthur Trewhella, Kylie Anne Wilkinson
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Abstract
The invention provides a method of synthesis of a substituted or unsubstituted carbinol compound, comprising the steps of subjecting the corresponding substituted or unsubstituted aromatic aldehyde to acyloin condensation mediated by yeast in the presence of either (a) a supereritical fluid or (b) a liquefied gas, and recovering the carbinol compound. Preferably the yeast is Saccharomyces cerevisiae. In a particularly preferred embodiment the aromatic aldehyde is benzaldehyde and the carbinol is phenylacetylcarbinol, according to the reaction (I): in which the benzaldehyde, the pyruvic acid, or both may optionally be substituted.
Claims7
A method of synthesis of a carbinol compound, comprising subjecting benzaldehyde to acyloin condensation using Saccharomyces yeast in the presence of supercritical carbon dioxide at a reaction temperature of 33° C. to 42° C. and a reaction pressure of 1500 psi to 2500 psi, and recovering the carbinol compound.
A method of synthesis of a carbinol compound, comprising subjecting benzaldehyde to acyloin condensation using Saccharomyces cerevisiae yeast in the presence of supercritical carbon dioxide, sodium pyruvate, and a citrate buffer at a reaction temperature of 35° C. and a reaction pressure of 2500 psi, and recovering the carbinol compound.
Dependencies are inferred from the claim text.