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US 7,063,967 B2Granted
Aminoalkyl glucosaminide phosphate compounds and their use as adjuvants and immunoeffectors
AssigneeCorixa Corporation
InventorsDavid A. Johnson, C. Gregory Sowell
Life of this patent
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Abstract
Aminoalkyl glucosaminide phosphate (AGP) compounds that are adjuvants and immunoeffectors are described and claimed. The compounds have a 2-deoxy-2-amino glucose in glycosidic linkage with an aminoalkyl (aglycon) group. Compounds are phosphorylated at the 4 or 6 carbon on the glucosaminide ring and comprise three 3-alkanoyloxyalkanoyl residues. The compounds augment antibody production in immunized animals as well as stimulate cytokine production and activate macrophages. Compositions and methods for using the compounds as adjuvants and immunoeffectors are also disclosed.
Claims13
A compound having the formula
- wherein X is O;
- Y is O;
- m, n, p and q are each 0;
- R4, R5, R7 and R9 are each H;
- R8 is phosphono;
- R6 is selected from OH, CO2H and CONH2;
- and R1, R2 and R3 are independently selected from C6 acyl groups and C10 acyl groups;
- or a pharmaceutically acceptable salt thereof.
5 more elements
Dependencies are inferred from the claim text.