US 7,063,965 B2 · Nucleic acid encoding TIE-2 ligand

Abstract

The present invention provides for an isolated nucleic acid molecule encoding a human TIE-2 ligand. In addition, the invention provides for a receptorbody which specifically binds a human TIE-2 ligand. The invention also provides an antibody which specifically binds a human TIE-2 ligand. The invention further provides for an antagonist of human TIE-2. The invention further provides for a ligandbody which specifically binds TIE-2 receptor. The invention also provides for therapeutic compositions as well as a method of blocking blood vessel growth, a method of promoting neovascularization, a method of promoting the growth, differentiation or migration of cells expressing the TIE-2 receptor, including, but not limited to, hematopoietic precursor cells, a method of blocking the growth, differentiation or migration of cells expressing the TIE-2 receptor including, but not limited to, hematopoietic precursor cells, and a method of attenuating or preventing tumor growth in a human.

Claims9

Dependent claims

An isolated nucleic acid molecule comprising a nucleotide sequence selected from the group consisting of:

(a) a nucleotide sequence encoding the fibrinogen-like domain of human TIE-2 ligand consisting of nucleotides 1197–1844 of SEQ ID NO:
5, and
(b) a nucleotide sequence which, due to the degeneracy of the genetic code, differs from the nucleotide sequence of (a) and which encodes the fibrinogen-like domain of human TIE-2 ligand, said fibrinogen-like domain of human TIE-2 ligand consisting of amino acids 281–496 of SEQ ID NO:6.

Dependencies are inferred from the claim text.

Facts

Application

10/603,293Filed 25 Jun 2003 · division

Priority

18 Nov 1999

Published

US 2005/0100906 A112 May 2005

Granted

20 Jun 2006

Term ends

Not estimatedThe source records don’t support an estimate.

Classification5 codes

A01K 67/0275
New or modified breeds of vertebrates: genetically modified vertebrates, e.g. transgenic
A01K 2217/05
Genetically modified animals: animals comprising random inserted nucleic acids
A01K 2227/105
Mammal: murine
A01K 2267/0306
Animal model, e.g. for test or diseases: animal model for genetic diseases

Family

PCT/US96/04806Parent of this continuation · filed 5 Apr 1996

Application09/442,717Parent of this division · filed 18 Nov 1999

US 2005/0100906 A1Pre-grant publication · published 12 May 2005

US 6,627,415 B1Parent of this division

Application08/930,721Parent of this continuation

Application09/442,717Parent of this continuation

US 7,063,965 B2This patent

From the US filing history. Foreign family members aren’t listed.

Nucleic acid encoding TIE-2 ligand

Life of this patent

Nucleic acid encoding TIE-2 ligand

Life of this patent

Abstract

Claims9