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US 7,063,963 B2Granted
Determined DNA sequences derived from a papillomavirus genome, their uses for in vitro diagnostic purposes and the production of antigenic compositions
AssigneeRoche Molecular Systems, Inc.
InventorsStewart Cole, Rolf E. Streeck
Life of this patent
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Abstract
The invention concerns DNA fragments derived from the genomic DNA of HPV-33. These fragments are selected from the group of fragments extending between the nucleotide extremities defined hereafter in relation to the nucleotide-numbering in FIGS. 1a and 1b respectively: 76–556 543–864 867–2811 2728–3808 3326–3575 3842–4079 4198–5611 5516–8091. The invention also relates to the use of these fragments as probes for the detection of HPV in tissue cultures.
Claims12
A method for detecting the presence of human papillomavirus in a sample comprising:
- combining a test sample containing sample nucleic acids with a composition comprising at least one nucleotide sequence from human papillomavirus-33, wherein the human papillomavirus-33 is defined by the sequence as shown in FIG. 1a and FIG. 1b;
- and
- identifying the presence of hybrids formed between said sample nucleic acids and said at least one nucleotide sequence from human papillomavirus-33.
Dependencies are inferred from the claim text.