Nucleic acids db, the receptor for leptin
AssigneeThe Rockefeller University
InventorsJeffrey M. Friedman, Gwo-Hwa Lee, Ricardo Proenca
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Abstract
The present invention relates to identification of a receptor for a satiety factor, which is involved in body weight homeostasis. Mutations in this receptor are associated with obese phenotypes. In particular, the present invention relates to identification and characterization of the receptor for leptin, including a naturally occurring soluble form of the receptor that is expected to modulate leptin activity, in particular to agonize leptin activity. The invention further relates to the nucleic acids encoding the receptor, and to methods for using the receptor, e.g., to identify leptin analogs, therapeutically, such as in gene therapy or in soluble form as an agonist or antagonist of leptin activity, or diagnostically.
Claims20
An isolated nucleic acid encoding a soluble leptin receptor polypeptide which is OB-Re (SEQ ID NO:10).
An isolated DNA molecule encoding on expression a soluble leptin receptor polypeptide selected from the group consisting of:
- a. a DNA molecule of SEQ ID NO:
- 9;
- and
- b. a DNA molecule that codes on expression for the soluble leptin receptor polypeptide encoded by the DNA molecule of subpart (a).
An isolated nucleic acid molecule having a nucleotide sequence corresponding or complementary to the DNA sequence set forth in SEQ ID NO:
- 9.
An isolated nucleic acid encoding a soluble leptin receptor selected from the group consisting of
- a) OB-Re (SEQ ID NO:
- 10);
- and
- b) a leptin receptor having amino acids 28–805 of SEQ ID NO:10.
Dependencies are inferred from the claim text.