System and method to simulate hemodynamics
AssigneeVictor Krstec
InventorsMichael B. Dancu, John M. Tarbell
Life of this patent
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Abstract
A system for hemodynamic simulation comprises a vessel having properties of a blood vessel, a reservoir containing a quantity of fluid, tubing connecting the vessel and reservoir, and at least one pump for circulating the fluid within the system. Fluid can be tissue culture medium or blood analog fluid, and the vessel may include mammalian cells attached to its inside. A drive system, comprising two reciprocating drive shafts that are coupled by a cam, enables the uncoupling of pulsatile flow and pulsatile pressure to provide independent control over wall shear stress and circumferential strain. The shaft drives two pumps that are 180 degrees out-of-phase and are connected upstream and downstream of the vessel, and effect this uncoupling.
Claims46
A system for hemodynamic simulation, the system comprising:
- a fluid;
- a vessel through which the fluid may be urged;
- a chamber in which the vessel is received, the chamber including a means for controlling pressure;
- a reservoir for retaining the fluid;
- a plurality of pumps in fluid communication with the fluid, one of the pumps urging the fluid through the vessel;
- and
- a means for controlling the pumps, wherein the means for controlling the pumps comprises a motor, a cam, and a means for linking the pumps, wherein the pumps are operatively connected to the means for controlling the pumps.
A system for hemodynamic simulation, the system comprising:
- a vessel through which the fluid may be urged;
- a chamber in which the vessel is received, the chamber including a means for controlling pressure;
- a reservoir for retaining the fluid;
- a plurality of pumps in fluid communication with the fluid, one of the pumps urging the fluid through the vessel;
- and
- a means for controlling the pumps, wherein the means for controlling the pumps is selected from the group consisting of a cam mechanism;
- a multi-bar linkage mechanism;
- a solenoid;
- a stepper motor;
- an electric motor;
- a linear ball actuator;
- a belt-driven actuator;
- and a chain-driven actuator.
A system for hemodynamic simulation, the system comprising:
- a fluid;
- a vessel through which the fluid may be urged;
- a chamber in which the vessel is received, the chamber including a means for controlling pressure;
- a reservoir for retaining the fluid;
- a plurality of pumps in fluid communication with the fluid, one of the pumps urging the fluid through the vessel;
- and
- a means for controlling the pumps comprising a motor, a cam, and a means for linking the pumps with each other, the pumps being operatively connected with the means for controlling the pumps, the means for linking the pumps being adjustable, the pumps being out of phase with each other.
A method for simulating biomechanical stimuli, the method comprising the steps of:
- providing a fluid;
- providing a vessel through which the fluid may be urged;
- providing a chamber for receiving the vessel therein, the chamber further including a means for controlling pressure, wherein said chamber is connected to a pump;
- providing an upstream pump in fluid communication with the fluid, the upstream pump urging the fluid through the vessel in a pushing manner;
- providing a downstream pump in fluid communication with the fluid, the downstream pump urging the fluid through the vessel in a pulling manner.
A method for hemodynamic simulation, the method comprising the steps of:
- providing a fluid;
- providing a vessel through which the fluid may be urged;
- providing a chamber in which the vessel is received, the chamber further including a means for controlling pressure;
- providing a reservoir for retaining the fluid;
- providing a plurality of pumps in fluid communication with the fluid, wherein one of said pumps urges the fluid through the vessel;
- and
- providing a means for controlling the pumps, comprising a motor, a cam, and a means for linking the pumps with each other, the pumps being operatively connected with the means for controlling the pumps, the means for linking the pumps being adjustable, the pumps being out of phase with each other.
A system for hemodynamic simulation, the system comprising:
- a vessel through which fluid may be urged;
- a chamber in which the vessel may be received, the chamber including a means for controlling pressure within the chamber and being connected to a pump;
- a reservoir suitable for retaining a fluid;
- and
- a plurality of pumps, one of said pumps being suitable for urging fluid through the vessel, wherein said pumps are operatively connected to the means for controlling the pumps, and wherein the means for controlling the pumps comprises a motor, a cam, and a means for linking the pumps.
Dependencies are inferred from the claim text.