Method of making a reversible matrix drug delivery system
AssigneeDe Montfort University
InventorMargaret Joan Taylor
Life of this patent
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Abstract
A method for producing a drug system which is a reversible gelled matrix with entrapped drug. The gel is made by combining a polysaccharide, such as dextran, a polymer of glucose, with a natural macromolecule, such as the lectin, concanavalin A, with binding sites for monomers of the polysaccharide. The drug is released in response to exposure of the matrix to free carbohydrate containing the monomer of the polysaccharide for which the natural macromolecule binds.
Claims39
A method of producing a system for delivering a drug or other biological agents, comprising the step of combining a reversible gelled matrix and the drug or other biological agents, wherein the reversible gelled matrix comprises a crosslinking agent and at least one receptor having a plurality of binding sites for a substrate in the environment of the matrix and for the crosslinking agent, the at least one receptor being activated in response to the levels of the substrate to effect a conformational change in the matrix allowing mobilisation and release of the drug or other biological agents into the environment, the conformational change in the matrix allowing mobilisation being effected by the binding of the substrate to the binding sites such that it displaces the crosslinking agent from the binding sites, and the conformational change in the matrix allowing immobilisation being effected by the binding of the crosslinking agent to the binding sites such that when the crosslinking agent becomes bound to the binding sites it displaces the substrate from the binding sites.
A system for delivering a drug or other biological agents, comprising a reversible gelled matrix containing an immobilised drug or other biological agents, wherein the reversible gelled matrix comprises a crosslinking agent and at least one receptor having a plurality of binding sites for a substrate in the environment of the matrix and for the crosslinking agent, the at least one receptor being activated in response to the levels of the substrate to effect a conformational change in the matrix allowing mobilisation and release of the drug or other biological agents into the environment, the conformational change in the matrix allowing mobilisation being effected by the binding of the substrate to the binding sites such that it displaces the crosslinking agent from the binding sites, and the conformational change in the matrix allowing immobilisation being effected by the binding of the crosslinking agent to the binding sites such that when the crosslinking agent becomes bound to the binding sites it displaces the substrate from the binding sites.
A method of producing a system for delivering a drug or other biological agents, comprising the step of combining:
- a drug or other biological agents;
- at least one polyfunctional branched polysaccharide crosslinking agent;
- and
- at least one polyfunctional receptor,
- wherein the at least one crosslinking agent and the at least one receptor form a reversible gelled matrix and the at least one receptor has a plurality of binding sites for a substrate in the environment of the matrix and for the crosslinking agent.
A method of producing a system for delivering a drug or other biological agents, comprising the step of combining a reversible gelled matrix and the drug or other biological agents, wherein the reversible gelled matrix comprises a crosslinking agent and at least one receptor having a plurality of binding sites for a substrate in the environment of the matrix and for the crosslinking agent while not having binding sites for the drug or other biological agents, the at least one receptor being activated in response to the levels of the substrate to effect a conformational change in the matrix allowing mobilisation and release of the drug or other biological agents into the environment, the conformational change in the matrix allowing mobilisation being effected by the binding of the substrate to the binding sites such that it displaces the crosslinking agent from the binding sites, and the conformational change in the matrix allowing immobilisation being effected by the binding of the crosslinking agent to the binding sites such that when the crosslinking agent becomes bound to the binding sites it displaces the substrate from the binding sites.
A system for delivering a drug or other biological agents, comprising a reversible gelled matrix containing an immobilised drug or other biological agents, wherein the reversible gelled matrix comprises a crosslinking agent and at least one receptor having a plurality of binding sites for a substrate in the environment of the matrix and for the crosslinking agent while not having binding sites for the drug or other biological agents, the at least one receptor being activated in response to the levels of the substrate to effect a conformational change in the matrix allowing mobilisation and release of the drug or other biological agents into the environment, the conformational change in the matrix allowing mobilisation being effected by the binding of the substrate to the binding sites such that it displaces the crosslinking agent from the binding sites, and the conformational change in the matrix allowing immobilisation being effected by the binding of the crosslinking agent to the binding sites such that when the crosslinking agent becomes bound to the binding sites it displaces the substrate from the binding sites.
A method of producing a system for delivering a drug or other biological agents, comprising the step of combining:
- a drug or other biological agents;
- at least one polyfunctional branched polysaccharide crosslinking agent;
- and
- at least one polyfunctional receptor,
- wherein the at least one crosslinking agent and the at least one receptor form a reversible gelled matrix and the at least one receptor has a plurality of binding sites for a substrate in the environment of the matrix and for the crosslinking agent while not having binding sites for the drug or biological agents.
A method of producing a system for delivering a drug or other biological agents, comprising the step of combining a reversible gelled matrix and the drug or other biological agents, wherein the reversible gelled matrix comprises a branched polysaccharide crosslinking agent and at least one lectin receptor having a plurality of binding sites for a substrate in the environment of the matrix and for the crosslinking agent, the at least one receptor being activated in response to the levels of the substrate to effect a conformational change in the matrix allowing mobilisation and release of the drug or other biological agents into the environment the conformational change in the matrix allowing mobilisation being effected by the binding of the substrate to the binding site such that it displaces the crosslinking agent from the binding sites, and the conformational change in the matrix allowing immobilisation being effected by the binding of the crosslinking agent to the binding sites such that when the crosslinking agent becomes bound to the binding sites it displaces the substrate from the binding sites.
Dependencies are inferred from the claim text.