Pharmaceutical composition containing aminocetonitrile compounds and the use thereof for the preparation of a pharmaceutical composition for the treatment of endoparasitic pests in animals
AssigneeNovartis Animal Health US, Inc.
InventorsPierre Ducray, Jacques Bouvier
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Abstract
The invention relates to a composition for controlling a pest, including endoparasites, and more specifically helminths, of formula (I) in animals, and methods related to thereof.
Claims3
A method of controlling an endoparasite in an animal comprising applying to said animal an effective amount of a compound selected from the group consisting of N-[1-(4-Chlorophenoxy)-2-cyanoprop-2-yl]-2-phenylacetamide, 1-Phenylcyclopropanecarboxylic acid [1-(4-Chlorophenoxy)-2-cyanoprop-2-yl]-amide, N-[2-(4-Chlorophenoxy)-1-cyanoethyl]-2-(2-chlorophenyl)-acetamide, N-[1-(4-Chlorophenoxy)-2-cyanoprop-2-yl]-2-(2-chlorophenyl)-acetamide, N-[3-(4-Chlorophenoxy)-2-cyanobut-2-yl]-2-(2chlorophenyl )-acetamide, N-[1-(4-Chlorophenoxy)-2-cyanobut-2-yl]-2-(2-chlorophenyl)-acetamide, N-[1-(4-Chlorophenoxy)-2-cyanopent-2-yl]-2-(2-chlorophenyl)-acetamide, N-[1-(4-Chlorophenoxy)-2-cyano-3-methylbut-2-yl]-2-(2-chlorophenyl)-acetamide, N-[2-(4-Chlorophenoxy)-1-cyano-1-cyclopropylethyl]-2-(2-chlorophenyl)-acetamide, N-[2-(4-Chlorophenoxy)-1-cyanocyclohexyl]-2-(2-chlorophenyl)-acetamide, N-[1-(4-Chlorophenoxy)-2-cyanoprop-2-yl]-2-(2-chlorophenyl)-N-ethylacetamide, N-[1-(4-Chlorophenoxy)-2-cyanoprop-2-yl]-2-(2-chlorophenyl)-N-butylacetamide, N-[1-(4-Chlorophenoxy)-2-cyanoprop-2-yl]-2-(2-chlorophenyl)-N-prop-2-ynylacetamide, N-[1-(4-Chlorophenoxy)-2-cyanoprop-2-yl]-2-(2-fluorophenyl)-acetamide, 1-(2-Fluorophenyl)-cyclopropanecarboxylic acid [1-(4-Chlorophenoxy)-2-cyanoprop-2-yl]-amide, N-[1-(4-Chlorophenoxy)-2-cyanobut-2-yl]-2-(3-chlorophenyl) -acetamide, N-[1-(4-Chlorophenoxy)-2-cyano-3-methylbut-2-yl]-2-(3-chlorophenyl)-acetamide, N-[2-(4-Chlorophenoxy)-1-cyano-1-cyclopropylethyl]-2-(3-chlorophenyl)-acetamide, 1-(3-Chloroph -cyclopropanecarboxylic acid [1-(4-Chlorophenoxy)-2-cyanoprop-2-yl]-amide, N-[1-Phenoxy-2-cyanoprop-2-yl]-2-(3-chlorophenyl)-acetamide, and the enantiomers thereof.
A composition for controlling an endoparasite in an animal, comprising a compound selected from the group consisting of N-[1-(4-Chlorophenoxy)-2-cyanoprop-2-yl]-2-phenylacetamide, 1-Phenylcyclopropanecarboxylic acid [1-(4-Chlorophenoxy)-2-cyanoprop-2-yl]-amide, N-[2-(4-Chlorophenoxy)-1-cyanoethyl]-2-(2-chlorophenyl)-acetamide, N-[1-(4-Chlorophenoxy)-2-cyanoprop-2-yl]-2-(2-chlorophenyl)-acetamide, N-[3-(4-Chlorophenoxy)-2-cyanobut-2-yl]-2-(2-chlorophenyl)-acetamide, N-[1-(4-Chlorophenoxy)-2-cyanobut-2-yl]-2-(2-chlorophenyl)-acetamide, N-[1-(4-Chlorophenoxy)-2-cyanopent-2-yl]-2-(2-chlorophenyl) -acetamide, N-[1-(4-Chlorophenoxy)-2-cyano-3-methylbut-2-yl]-2-(2-chlorophenyl)-acetamide, N -[2-(4-Chlorophenoxy)-1-cyano-1-cyclopropylethyl]-2-(2-chlorophenyl)-acetamide, N-[2-(4-Chlorophenoxy)-1-cyanocyclohexyl]-2-(2-chlorophenyl)-acetamide, N-[1-(4-Chlorophenoxy)-2-cyanoprop-2-yl]-2-(2-chlorophenyl)-N-ethylacetamide, N-[1-(4-Chlorophenoxy)-2-cyanoprop-2-yl]-2-(2-chlorophenyl)-N-butylacetamide, N-[1-(4-Chlorophenoxy)-2-cyanoprop-2-yl]-2-(2-chlorophenyl)-N-prop-2-ynylacetamide, N-[1-(4-Chlorophenoxy)-2-cyanoprop-2-yl]-2-(2-fluorophenyl)-acetamide, 1-(2-Fluorophenyl)-cyclopropanecarboxylic acid [1-(4-Chlorophenoxy) -2-cyanoprop-2-yl]-amide, N-[1-(4-Chlorophenoxy)-2-cyanobut-2-yl]-2-(3-chlorophenyl) -acetamide, N-[1-(4-Chlorophenoxy)-2-cyano-3-methylbut-2-yl]-2-(3-chlorophenyl)-acetamide, N -[2-(4-Chlorophenoxy)-1-cyano-1-cyclopropylethyl]-2-(3-chlorophenyl)-acetamide, 1-(3-Chlorophenyl)-cyclopropanecarboxylic acid [1-(4-Chlorophenoxy)-2-cyanoprop-2-yl]-amide, and N-[1-Phenoxy-2-cyanoprop-2-yl]-2-(3-chlorophenyl)-acetamide, and a pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.