Herpes viruses for immune modulation
AssigneeBiovex Limited
InventorRobert S. Coffin
Life of this patent
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Abstract
A method of stimulating an immune response in a human or animal subject, which method comprises administering to a subject in need thereof an effective amount of an attenuated herpes virus which: (i) lacks a functional vhs gene, or a functional equivalent thereof; (ii) lacks a functional ICP47 gene, or a functional equivalent thereof; and (iii) is incapable of expressing a substantial amount of functional ICP22, or a functional equivalent thereof, in mammalian dendritic cells.
Claims36
A method of stimulating an immune response in a human or animal subject, which method comprises administering to a subject in need thereof an effective amount of an attenuated herpes virus which:
- (i) lacks a functional vhs gene, or a functional equivalent thereof;
- (ii) lacks a functional ICP47 gene, or a functional equivalent thereof;
- (iii) is incapable of expressing a substantial amount of functional ICP22, or a functional equivalent thereof, in mammalian dendritic cells;
- and
- (iv) comprises a functional UL43 gene
- such that dendritic cells are infected with said virus.
An isolated dendritic cell infected with an attenuated herpes virus which:
- (i) lacks a functional vhs gene, or a functional equivalent thereof;
- (ii) lacks a functional ICP47 gene, or a functional equivalent thereof;
- (iii) is incapable of expressing a substantial amount of functional ICP22, or a functional equivalent thereof, in mammalian dendritic cells;
- and
- (iv) comprises a functional UL43 gene.
A method of activating dendritic cells, which method comprises infecting dendritic cells with an attenuated herpes virus which:
- (i) lacks a functional vhs gene, or a functional equivalent thereof;
- (ii) lacks a functional ICP47 gene, or a functional equivalent thereof;
- (iii) is incapable of expressing a substantial amount of functional ICP22, or a functional equivalent thereof, in mammalian dendritic cells;
- and
- (iv) comprises a functional UL43 gene.
Dependencies are inferred from the claim text.