Lipoglycan compositions and methods of treating parasitic infections
AssigneeUniversity of Massachusetts
InventorLloyd H. Semprevivo
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Abstract
A composition for and a method of eliciting in a vertebrate a protective immune response against an eukaryotic parasite are disclosed. The method includes administering to the vertebrate a composition having a carrier group coupled to an oligosaccharide obtained from a lipoglycan found on the surface of an eukaryote. The composition is administered in an amount sufficient to elicit a protective immune response against the parasite.
Claims32
A method of eliciting in a vertebrate a protective immune response against a parasitic protozoan or platyhelminth having a surface coat comprising a lipoglycan, the method comprising administering to the vertebrate a composition comprising a carrier group coupled to an oligosaccharide obtained from a lipoglycan, wherein the lipoglycan comprises a lipid group, one or more fucose groups, three to five galactoseamine groups per fucose group, two to four glucosamine groups per fucose group, one to two galactose groups per fucose group, one to two glucose groups per fucose group, one to two rhamnose groups per fucose group, and one to three mannose groups per fucose group, the composition being administered in an amount sufficient to elicit a protective immune response against the parasitic protozoan or platyhelminth.
A method of eliciting in a vertebrate a protective immune response against a parasitic protozoan or platyhelminth having a surface coat comprising a lipoglycan, the method comprising administering to the vertebrate a composition comprising a carrier group coupled to an oligosaccharide obtained from a lipoglycan, wherein the lipoglycan comprises a lipid group, one or more fucose groups, three to five galactoseamine groups per fucose group, seven to eleven glucoseamine groups per fucose group, three to five galactose groups per fucose group, one to two glucose groups per fucose group, and three to five mannose groups per fucose group, the composition being administered in an amount sufficient to elicit a protective immune response against the parasitic protozoan or platyhelminth.
Dependencies are inferred from the claim text.