Presentation of hydrophobic antigens to T-cells by CD1 molecules
AssigneeThe Brigham and Women's Hospital, Inc.
InventorsSteven A. Porcelli, Michael B. Brenner, Evan M. Beckman, Stephen T. Furlong
Life of this patent
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Abstract
Provided are CD-1 presented antigens, compositions, cells, inhibitors and methods relating to the use of hydrophobic antigen presentation by CD1 molecules, including: methods for detecting the presence of a CD1-presented hydrophobic antigen in a sample; methods for isolating such CD1-presented antigens and isolated antigens; vaccines containing CD1-presented antigens and vaccination methods; methods of blocking CD1 antigen presentation; methods of identifying and/or isolating CD1 blocking agents and the isolated CD1 blocking agents; methods of inducing CD1 expression; and T-cells for use in the methods disclosed herein.
Claims16
A method for inhibiting presentation of a CD1b restricted antigen by CD1b+ cells, comprising the step of:
- contacting cells displaying a CD1b molecule with a CD1b blocking agent which inhibits CD1b-restricted antigen presentation, said agent comprising an antibody that binds to the CD1b molecule and blocks the interaction of said CD1b molecule with the CD1b-restricted antigen.
A method for inhibiting presentation of a CD1b restricted antigen by CD1c+ cells, comprising the step of:
- contacting cells displaying a CD1c molecule with the CD1c blocking agent which inhibits CD1c-restricted antigen presentation, said agent comprising an antibody that binds to the CD1c molecule and blocks the interaction of said CD1c molecule with the CD1c-restricted antigen, wherein the contacting occurs in vivo.
A method for inhibiting presentation of a CD1a restricted antigen by CD1a+ cells, comprising the step of:
- contacting cells displaying a CD1a molecule with a CD1a blocking agent which inhibits CD1a-restricted antigen presentation, said agent comprising an antibody that binds to the CD1a molecule and blocks the interaction of said CD1a molecule with the CD1a-restricted antigen.
A method for inhibiting presentation of a CD1d restricted antigen by CD1d+ cells, comprising the step of:
- contacting cells displaying a CD1d molecule with a CD1d blocking agent which inhibits CD1d-restricted antigen presentation, said agent comprising an antibody that binds to the CD1d molecule and blocks the interaction of said CD1d molecule with the CD1d-restricted antigen.
A method for inhibiting CD1c-restricted antigen presentation by CD1c+ cells, comprising the step of:
- contacting cells displaying a CD1c molecule with a CD1c blocking agent which inhibits CD1c-restricted antigen presentation, said agent comprising an antibody, wherein the contacting occurs in vivo.
A method for inhibiting CD1a-restricted antigen presentation by CD1a+ cells, comprising the step of:
- contacting cells displaying a CD1a molecule with a CD1a blocking agent which inhibits CD1a-restricted antigen presentation, said agent comprising an antibody.
A method for inhibiting CD1d-restricted antigen presentation by CD1d+ cells, comprising the step of:
- contacting cells displaying a CD1d molecule with a CD1d blocking agent which inhibits CD1d-restricted antigen presentation, said agent comprising an antibody.
Dependencies are inferred from the claim text.