Compounds and methods for inhibiting the interaction between α-catenin and β-catenin
AssigneeMcGill University
InventorsOrest W Blaschuk, Barbara J Gour
Life of this patent
Estimating the term…
Abstract
Modulating agents for inhibiting an interaction between α-catenin and β-catenin are provided. The modulating agents comprise one or more of: (a) a β-catenin HAV motif; (b) a peptide analogue or mimetic of a β-catenin HAV motif; or (c) an antibody or antigen-binding fragment thereof that specifically binds to a β-catenin HAV motif. Methods for using such modulating agents for inhibiting cadherin-mediated cell adhesion in a variety of contexts are also provided.
Claims5
A modulating agent capable of inhibiting an interaction between α-catenin and β-catenin, comprising one or more of:
- (a) the amino acid sequence KHAVV (SEQ ID NO:1);
- or
- (b) an antibody or antigen-binding fragment thereof that specifically binds to a peptide comprising the amino acid sequence KHAVV (SEQ ID NO:1).
A pharmaceutical composition comprising a modulating agent comprising one or more of:
- (a) the amino acid sequence KHAVV (SEQ ID NO:1);
- (b) a peptide analogue of the amino acid sequence KHAVV (SEQ ID NO:1) having conservative substitutions at one or more residues flanking the amino acid sequence HAV;
- or
- (c) an antibody or antigen-binding fragment thereof that specifically binds to a peptide comprising the amino acid sequence KHAVV (SEQ ID NO:1);
- in combination with a pharmaceutically acceptable carrier.
A method for modulating cell adhesion comprising contacting a cell with a modulating agent comprising one or more of:
- (a) the amino acid sequence KHAVV (SEQ ID NO:1);
- (b) a peptide analogue of the amino acid sequence KHAVV (SEQ ID NO:1) having conservative substitutions at one or more residues flanking the amino acid sequence HAV;
- or
- (c) an antibody or antigen-binding fragment thereof that specifically binds to a peptide comprising the amino acid sequence KHAVV (SEQ ID NO:1).
Dependencies are inferred from the claim text.