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US 7,063,841 B2Granted
Mammalian cell surface antigens; related reagents
AssigneeSchering Corporation
InventorsDaniel E. Gorman, Jeanine D. Mattson
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Abstract
Purified genes encoding a T cell surface antigen from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding this antigen are provided. Methods of using said reagents and diagnostic kits are also provided.
Claims10
A method for treating rheumatoid arthritis in an animal, comprising providing to the animal an effective amount of an antagonist of 499E9, wherein the antagonist is selected from the group consisting of:
- (a) antibodies that specifically bind to a 499E9 polypeptide having the amino acid sequence SEQ ID NO:2;
- (b) binding compounds comprising the antigen-binding fragments of the antibodies of (a);
- and
- (c) polypeptide antagonists of the 499E9 protein, wherein the polypeptides exhibit 100% sequence identity over a length of at least 12 contiguous amino acids to SEQ ID NO:
- 2.
2 more elements
Dependencies are inferred from the claim text.