Methods for treating an artery or vein in a human subject
AssigneeProteon Therapeutics, Inc.
InventorNicholas F. Franano
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Abstract
The invention provides methods for treating an obstructed biological conduit that include administering to the conduit an agent that can degrade extracellular matrix of obstructing tissue. Particular methods include delivery of an enzyme or a mixture of several enzymes to the area or region of obstruction wherein the enzyme(s) have the capability to degrade extracellular matrix components within the obstruction thereby restoring the normal flow of transported fluid through the conduit. The invention also includes preventively dilating a section of conduit to minimize the risk of obstruction formation.
Claims18
A method for treating an obstructed artery or vein in a human subject in need of such treatment, the method comprising:
- locally administering to the wall of the artery or vein in the human subject a composition comprising an elastase,
- wherein administration of the composition results in proteolysis of elastin in the wall of the artery or vein leading to enlargement of the diameter of the artery or vein.
A method for treating an artery or vein connected to an arteriovenous hemodialysis graft in a human subject in need of such treatment, the method comprising:
- locally administering to the wall of the artery or vein in the human subject a composition comprising an elastase,
- wherein administration of the composition results in proteolysis of elastin in the wall of the artery or vein leading to enlargement of the diameter of the artery or vein.
A method for treating a vein in a human subject for use in hemodialysis, the method comprising:
- locally administering to the wall of the vein in the human subject a composition comprising an elastase,
- wherein administration of the composition results in proteolysis of elastin in the wall of the vein leading to enlargement of the diameter of the vein.
Dependencies are inferred from the claim text.