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US 7,063,837 B2Granted
Syrup composition containing phage associated lytic enzymes
AssigneesNew Horizons Diagnostics Corporation, The Rockefeller University
InventorsVincent Fischetti, Lawrence Loomis
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Abstract
The present invention discloses a method and composition for the treatment of bacterial infections by the parenteral introduction of at least one lytic enzyme produced by a bacteria infected with a bacteriophage specific for that bacteria and an appropriate carrier for delivering the lytic enzyme into a patient. The injection can be done intramuscularly, subcutaneously, or intravenously.
Claims19
A parenteral therapeutic agent for the treatment of bacterial infections comprising:
- a) an effective amount of at least one enzyme genetically coded for by at least one specific bacteriophage specific for a specific bacteria, wherein said at least one enzyme is selected fro the group consisting of at least one unaltered lytic enzyme, at least one shuffled lytic enzyme, at least one chimeric lytic enzyme at least one holin protein, and combinations thereof, said at least one enzyme having the ability to digest a cell wall of a specific said bacteria;
- b) a parenteral carrier for the parenteral delivery of said at least one lytic enzyme to the site of the infection, said parenteral carrier comprising:
- i) a fluid selected from the group consisting of distilled water, a saline solution, albumin, a serum, and any combinations thereof;
- ii) supplemental additive selected from the group consisting of saline, buffer, and combinations thereof;
- and
- iii) nutritional agents selected from the group consisting of dextrose, mannitol, sorbitol, lactose, gelatin, and combinations thereof.
3 more elements
Dependencies are inferred from the claim text.