US 7,063,720 B2 · Covered stent with controlled therapeutic agent diffusion

Abstract

A covered stent includes a generally tubular stent body having inner and outer stent body surfaces. A sleeve of porous material encloses the stent body and has inner and outer portions opposed to the inner and outer stent body surfaces. A therapeutic agent is located along the stent body, the agent being diffusible through the material. A diffusion barrier is located between the inner material portion and the agent along the stent. The diffusion barrier prevents passage of at least a significant amount the agent through the inner portion of the sleeve of porous material. A diffusion restrictor is located between the outer portion of the sleeve of porous material and the agent along the stent. The diffusion restrictor permits passage of the agent through the inner material portion at a therapeutic level.

Claims20

Dependent claims

A covered stent comprising:

a generally tubular stent body having inner and outer stent body surfaces;
a sleeve of porous material enclosing the stent body, the sleeve of material having inner and outer material portions opposed to the inner and outer stent body surfaces;
a therapeutic agent along the stent body, the agent being diffusible through the sleeve of porous material;
a diffusion restrictor between the outer material portion and the agent along the stent, said diffusion restrictor permitting passage of the agent through the inner material portion at a first, therapeutic rate;
and
a diffusion barrier between the inner material portion and the agent along the stent, said diffusion barrier preventing passage of the agent through the inner material portion at at most a second rate, the second rate being less than the first rate.

3 more elements

A covered stent comprising:

a generally tubular stent body having an inner and outer stent body surfaces;
a sleeve of porous material enclosing the stent body, the sleeve of material having inner and outer material portions opposed to the inner and outer stent body surfaces;
a hydrophilic anti-restenotic therapeutic agent/silicone carrier matrix adhering to the stent body, the agent being diffusible through the sleeve of porous material;
a diffusion restrictor applied onto the therapeutic agent/silicone carrier matrix along the stent, said diffusion restrictor permitting passage of the agent through the inner material portion at a first, therapeutic rate;
a diffusion barrier applied onto the therapeutic agent/silicone carrier matrix along the stent, said diffusion barrier preventing passage of the agent through the inner material portion at at most a second rate, the second rate being less than the first rate;
and
the diffusion restrictor and the diffuser barrier comprising Parylene.

4 more elements

Dependencies are inferred from the claim text.

Covered stent with controlled therapeutic agent diffusion

Life of this patent

Covered stent with controlled therapeutic agent diffusion

Life of this patent

Abstract

Claims20