Implantable reservoir and system for delivery of a therapeutic agent
AssigneeRegents of the University of Minnesota
InventorsRandall S. Nelson, Charles L. Truwit
Life of this patent
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Abstract
There is disclosed method and apparatus for retaining a reservoir for a therapeutic agent between the scalp and cranium of a subject, including providing a deformable pouch or rigid cylinder for dispensing the therapeutic agent from the reservoir to a location in the body of the subject. In one embodiment, a pump is used to pump the agent from the reservoir to the location in the subject's body. In another example embodiment, there is provided method and apparatus for forming at least one cavity in the cranium of the subject, and placing at least a portion of the pump in the cavity. Power is applied to the pump in a variety of ways.
Claims64
A method comprising:
- retaining a reservoir for a therapeutic agent between the scalp and cranium of a subject;
- and
- deploying the reservoir in the space between the scalp and cranium using one or more deployment lines connected at or near the edge of the reservoir that when pulled deploy the reservoir in a desired position.
A method comprising:
- retaining a reservoir for a therapeutic agent between the scalp and cranium of a subject;
- and
- anchoring the reservoir by suturing to the subject's galea.
A method comprising:
- retaining a reservoir for a therapeutic agent between the scalp and cranium of a subject, wherein the reservoir is hermetically sealed with a metal;
- and
- further wherein one end of the reservoir has a fixed dimension and contains an outlet port and a filling port, with the opposing end having a non-fixed dimension and is activated by a push rod or piston mechanism to predictably collapse the reservoir while pushing the therapeutic agent out under constant pressure.
A method comprising:
- retaining a reservoir for a therapeutic agent between the scalp and cranium of a subject, wherein the reservoir is a solid cylinder with the outlet port or valve mechanism located on one end of the cylinder, and the opposing end is fitted with a push rod/sealing piston to retain the therapeutic agent and to force the therapeutic agent through the outlet port.
A method comprising retaining a reservoir for a therapeutic agent between the scalp and cranium of a subject, wherein the reservoir is hermetically sealed with a metal and the reservoir is a square or round hollow, rigid tube coiled to maintain a flat or specifically shaped profile of minimum surface area, and the reservoir is filled through an inflow valve located at or near one end of the tube, and the outflow port is located at the opposite end of the tube from the filling port.
A method according to 33 including transcutaneously transmitting power to the power source to recharge the power source.
A method according to 39 wherein the external device reprograms the electronic circuitry as necessary, and collects and displays data as transmitted from the implantable device.
A method comprising:
- retaining a reservoir for a therapeutic agent between the scalp and cranium of a subject;
- and
- dispensing the therapeutic agent from the reservoir to a location in the brain of the subject, wherein the agent is dispensed by pumping it to the location in the subject's body with a pump, the pump is a diaphragm pump or piston pump that controls dosage volume by change in volume per stroke X number of strokes, and further including controlling the flow of agent using a first valve to regulate the inflow and a second valve to regulate the outflow wherein the inflow valve is a mechanical valve displaced by the refill needle.
A method comprising:
- retaining a reservoir for a therapeutic agent between the scalp and cranium of a subject;
- and
- dispensing the therapeutic agent from the reservoir to a location in the brain of the subject, wherein the agent is dispensed by pumping it to the location in the subject's body with a pump, the pump is a diaphragm pump or piston pump that controls dosage volume by change in volume per stroke X number of strokes, and further including controlling the flow of agent using a first valve to regulate the inflow and a second valve to regulate the outflow wherein the inflow valve is an electronically controlled valve that is activated by an external device at the time of filling.
A method comprising:
- retaining a reservoir for a therapeutic agent between the scalp and cranium of a subject;
- and
- dispensing the therapeutic agent from the reservoir to a location in the brain of the subject, wherein the agent is dispensed by pumping it to the location in the subject's body with a pump, the pump is a diaphragm pump or piston pump that controls dosage volume by change in volume per stroke X number of strokes, and further including controlling the flow of agent using a first valve to regulate the inflow and a second valve to regulate the outflow wherein the outflow valve is electronically controlled and timed to the outflow cycle of the pump.
A method comprising:
- retaining a reservoir for a therapeutic agent between the scalp and cranium of a subject;
- and
- dispensing the therapeutic agent from the reservoir to a location in the brain of the subject, wherein the agent is dispensed by pumping it to the location in the subject's body with a pump, the pump is a diaphragm pump or piston pump that controls dosage volume by change in volume per stroke X number of strokes, and further including controlling the flow of agent using a first valve to regulate the inflow and a second valve to regulate the outflow wherein the outflow valve is a normally closed valve located at the distal end of a catheter carrying the therapeutic agent to the location in the subject's body, and when therapeutic agent delivery is required, the valve is electrically opened and remains open for a programmed period of time.
A method comprising:
- retaining a reservoir for a therapeutic agent between the scalp and cranium of a subject;
- dispensing the therapeutic agent from the reservoir to a location in the brain of the subject, wherein the agent is dispensed by pumping it to the location with a pump, while an external power source is placed over the site of the pump;
- and
- retaining an implanted power source within the subject's body wherein the power source powers the pump, and the power source is rechargeable.
A method comprising:
- retaining a reservoir for a therapeutic agent between the scalp and cranium of a subject;
- dispensing the therapeutic agent from the reservoir to a location in the brain of the subject, wherein the agent is dispensed by pumping it to the location with a pump;
- retaining an implanted power source within the subject's body wherein the power source powers the pump, and the power source is rechargeable;
- and
- forming at least one cavity in the cranium of the subject, and placing at least a portion of the power source in the cavity.
A method comprising:
- retaining a reservoir for a therapeutic agent between the scalp and cranium of a subject;
- and
- dispensing the therapeutic agent from the reservoir to a location in the brain of the subject, wherein the agent is dispensed by pumping it to the location in the subject's body with a pump and further including positioning the power source under the skin behind the ear of the subject.
A method comprising:
- retaining a reservoir for a therapeutic agent between the scalp and cranium of a subject;
- and
- forming at least two cavities in the cranium of the subject, and placing at least a portion of a pump in one cavity and at least a portion of a power source for the pump in the other cavity.
A method comprising:
- retaining a reservoir for a therapeutic agent between the scalp and cranium of a subject, wherein a pump and power source are housed integral to the pump and reservoir;
- and
- dispensing the therapeutic agent from the reservoir to a location in the brain of the subject.
Dependencies are inferred from the claim text.