Systems for differential ion mobility analysis
AssigneesSionex Corporation, The Charles Stark Draper Laboratory, Inc.
InventorsRaanan A. Miller, Erkinjon G. Nazarov, Angela Zapata, Cristina E. Davis, Gary A. Eiceman, Anthony D. Bashall
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Abstract
Disclosed herein are systems, methods and apparatus, for detection and identification of analytes in a volatilized or volatilizable sample, using the mobility-based signature that is produced when the volatilized sample is passed through a differential ion mobility spectrometry (DMS) device.
Claims51
A method of detection and identification of analytes in a sample based on at least an aspect of ion mobility, comprising:
- (a) obtaining a volatilized sample comprising markers that are detectable by ion mobility;
- and
- (b) directing at least a portion of the volatilized sample to a differential ion mobility detection spectrometry (DMS) device, to obtain a mobility-based signature of at least one marker, wherein the mobility-based signature correlates with the analytes,
- thereby detecting and identifying at least one analyte in the sample.
A method of detection and identification of analytes in a sample, comprising:
- (a) volatilizing at least a portion of the sample to produce a volatilized sample that includes markers detectable by an aspect of ion mobility;
- and
- (b) directing at least a portion of the volatilized sample to a differential ion mobility detection spectrometry (DMS) device, to obtain a mobility-based signature of at least one marker, wherein the mobility-based signature correlates with the analytes,
- thereby detecting and identifying at least one analyte in the sample.
A device for analysis of biological or chemical samples using an aspect of ion mobility, comprising:
- (a) a volatilization part;
- and
- (b) differential ion mobility spectrometry (DMS) device, connected to said volatilization part.
A field asymmetric ion mobility detection system, comprising:
- an input part and an output part, said input part including a volatilization part;
- at least a pair of spaced insulated substrates cooperating to define between them an enclosed flow path for the flow of ions from the input part to the output part;
- at least two electrodes opposite each other and defined in the flow path, the at least two electrodes including at least one filter electrode associated with each substrate to form an ion filter section;
- and
- an electronics part configured to apply controlling signals to the electrodes, and the electronics part applying an asymmetric periodic signal across the filter electrodes for filtering the flow of ions in the flow path, said filter being compensated to pass desired ion species out of the filter section.
A method of detection and identification of analytes in a sample by an ion-mobility based device, comprising:
- (a) directing a portion of a sample into a first separation device thereby obtaining a first profile;
- (b) directing a portion of a sample into a second separation device thereby obtaining a second profile, wherein at least one of the first and the second separation devices is a DMS device;
- and
- (c) combining the first and the second profiles thereby identifying at least one analyte in a sample.
Dependencies are inferred from the claim text.